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Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep ,,, Technology

lvent background noise was greatly reduced for ESI full-scan analysis in negative ion mode. This decrease in background/chemical noise and correlating increase in S/N significantly enhances the information content of the Data-Dependent experiment by reducing the number of nonsense spectra collected, a consequence of chemical noise triggering an MS/MS acquisition. The ion source was also subjected to over 200 injections of alprazolam in crashed bovine plasma without significant signal roll-off over a 24-hour period. The use of new Ion Sweep technology results in a more sensitive ion trap mass spectrometer with the added benefit of enhanced ion source robustness.
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