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Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep ,,, Technology

ter the solvent-adducts. Figure 9: Negative ESI base peak chromatogram of imazethapyr (RT 9.6 min, m/z 288) without Ion Sweep gas. a) Solvent-adduct ions overwhelm the signal in the base peak chromatogram making detection of the analyte difficult, at best. b) The mass spectrum has a base peak of 136.6, corresponding to ammonium acetate clusters/adducts from the solvent. Elimination of the solventadduct ions cleans up the full-scan MS trace, as shown in Figure 10. Imazethapyr can now be detected at 9.7 min in the base peak chromatogram (Figure 10a), allowing for accurate and efficient Data-Dependant analysis. Figure 10b also shows the drastic reduction of solvent adducts by the use of Ion Sweep gas, as the base peak is the molecular ion at m/z 288. Figure 10: Negative ESI base peak chromatogram of imazethapyr (m/z 288) using Ion Sweep gas. a) Solvent-adduct ions are reduced compared with analysis without Ion Sweep gas (Figure 9a) and imazethapyr is detected in the base peak chromatogram at 9.7 min. b) The mass spectrum shows a base peak at m/z 288, the molecular ion for imazethapyr; the presence of adduct ions (m/z 136.7) is greatly reduced compared to analysis without Ion Sweep gas (Figure 9b). Conclusions The new Thermo Finnigan API source with Ion Sweep technology resulted in a dramatic improvement in S/N in full-scan MS mode. The examples presented illustrate the decrease in chemical noise when Ion Sweep gas is used for full-scan MS analyses, thereby resulting in increased S/N. The performance enhancement for APCI in full-scan MS mode was remarkable, while so
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