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Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep ,,, Technology

advantage of using Ion Sweep gas in full-scan MS mode, especially when the analysis requires scanning from m/z 150 and higher. Figure 5: Flow injection analysis of buspirone without use of Ion Sweep gas. The presence of solvent adduct ions at m/z 160 overwhelm the buspirone signal at m/z 386.4 in both a) the base peak chromatogram and b) mass spectrum.

Figure 6: Flow injection analysis of buspirone using Ion Sweep gas at a setting of 10 arbitrary units. The base peak chromatogram (a) clearly shows dramatic improvement in S/N when compared with analysis without use of Ion Sweep gas (Figure 5). Solvent adduct ions are absent from the mass spectrum (b) which shows a base peak of 386.4, the molecular ion for buspirone. Figures 7 and 8 illustrate the utility of Ion Sweep gas during ESI full-scan LC-MS positive ion analysis for paclitaxel (Taxol) (m/z 854). Taxol is present in a nine component test mixture and elutes at 30.1 min. Figure 7 is a chromatogram and mass spectrum without the use of Ion Sweep gas. Taxol is barely visible in the baseline of the chromatogram. As can be seen from the mass spectrum, the ammonium adduct, [M+17]+ (m/z 871), is the base peak. Ion Sweep gas is useful in reducing the formation of the ammonium adduct and allows for unambiguous determination of molecular weight, as observed in Figure 8. The background is reduced, allowing better detection of the Taxol peak in the base peak chromatogram. Furthermore, a clear advantage of Ion Sweep is the ability to trigger Data-Dependent full-scan MS/MS on the basis of the molecular ion rather than the ammonium adduct, as m/z 854 is
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