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Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep ,,, Technology

n gas from the auxiliary gas line is plumbed through the API flange and exits the Ion Sweep cap through the openings of the three tubes positioned in front of the ion transfer tube orifice. The flow of nitrogen gas over the opening of the ion transfer tube ensures that the ions pierce this gentle stream of nitrogen gas as they travel into the ion transfer tube. Solvent clusters formed in the probe region interact with the nitrogen gas and dissociate before they enter the ion transfer tube. Furthermore, a small amount of the Ion Sweep nitrogen gas is drawn into the ion source, where the gas plays an important role in eliminating adduct formation during the free jet expansion.

Influence on ion source robustness
The physical presence of the Ion Sweep cap, combined with the flowing nitrogen gas, increases the overall ion source robustness by gently sweeping the front face of the ion transfer tube, thereby protecting it from contaminant build-up. Figure 2 shows over 200 injections of alprazolam in crashed bovine plasma analyzed over a 24-hour period. No significant decrease in signal intensity was observed, testifying to the increased ruggedness due to Ion Sweep technology.

Improving full-scan MS S/N
Figures 3 through 6 illustrate the power of Ion Sweep technology on eliminating solvent ion noise in the low m/z region (100-250) during APCI full-scan MS flow injection analysis (FIA). Figures 3 and 4 show five injections of caffeine (m/z 195.3) with and without the use of Ion Sweep gas, respectively. Figure 2: Multiple injections of alprazolam in crashed bovine plasma. No loss in signal intensity was observed over 200 injections within a 24-hour t
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