Navigation Links
Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep ,,, Technology

combination with orthogonal electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) probes has resulted in a dramatic reduction in API solvent ion noise and overall increased source robustness. Examples of increased robustness and solvent noise reduction in the full-scan MS mode when using Ion Sweep gas clearly illustrate the power of Ion Sweep technology that is now standard on both LCQ Deca XP Plus and LCQ Advantage platforms. Goal This report demonstrates the improvements in robustness and full-scan MS sensitivity observed when Ion Sweep technology is utilized. Both APCI and ESI techniques are examined. Several small molecules ranging from m/z 190900 were selected for APCI and ESI LC/MS assays to illustrate the improvement in full-scan performance of the API source using Ion Sweep technology. Repeated injections of alprazolam in plasma were performed to emphasize the robustness of the source when Ion Sweep is used. Experimental Conditions Surveyor MS Pump: 400 L/min
Surveyor Autosampler
Thermo Finnigan LCQ Deca XP Plus mass spectrometer with Ion Sweep Cap
Ion transfer tube temperature: 275-300C
APCI corona discharge current: 4.8 A (probe position: 2C)
ESI spray voltage: 5kV
(probe position: 3C)
Sheath gas: 45-65 au
Ion Sweep Gas: 10 au (using auxiliary gas line)
HPLC conditions: variable; see figure legends for details Figure 1: Picture of the Ion Sweep cap Discussion Theory
The Ion Sweep cap is shown in Figure 1. Nitroge
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8

Related biology technology :

1. Novel PCR Enhancing Factor Improves Performance of Pfu DNA Polymerase
2. Enhancing PCR* Efficiency with MasterTaq
3. Improved Sensitivity for Staining RNA with SYBR Gold Stain
4. Increase the Power and Sensitivity for Your cDNA Synthesis with the New Transcriptor Reverse Transcriptase
5. Increased Sensitivity in Microarray Analysis
6. Femtogram Sensitivity of the Antipsychotic Drugs Raclopride and Ritanserin Using a Varian 1200L LC/MS/MS
7. Maintaining High Sensitivity when Working with Small-Volume Samples
8. High Sensitivity, Wide Dynamic Range, Horseradish Peroxidase (HRP) ELISA Using the LMax Microplate Luminometer (MaxLine Application Note #41)
9. Sensitivity and Quantitation using a Finnigan LCQ Deca XP Plus Ion Trap Mass Spectrometer
10. Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery
11. Trace Analysis Optimizing Sensitivity Finnigan Surveyor PDA Detector
Post Your Comments:
(Date:10/22/2014)... 2014 Shimadzu Scientific Instruments introduces its ... for the pain management and clinical markets. The software ... review by allowing users to highlight and review results ... QuantAnalytics allows analysts to filter results by group or ... by eliminating the need to sift through analytes of ...
(Date:10/22/2014)... Cranford, NJ (PRWEB) October 22, 2014 ... technologies and services – has been working with a ... Health and New Haven Farms Community Farming Collaborative to ... iPad-based ePRO solution. The study, which started in ... Wellness program that provides participants weekly exposure to and ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Grace Century, ... and healthcare projects, announces the addition of Dr. ... to its advisory team. Dr. Siddiqui will provide further ... , A graduate of University College Medical School ... degreed in medicine in 2001. With further certification as ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 According ... Market by Service Type (Consulting, Integration, Deployment & ... by Deployment Model (Public, Private, Others (Hybrid & ... MarketsandMarkets, defines and segments the Cloud Professional Services ... and forecasting of revenues. It also identifies the ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5
... SAN DIEGO, Feb. 3 Gen-Probe Incorporated (Nasdaq: ... has joined the Company as senior vice president, research ... expertise and leadership to our already strong senior management ... officer. "We believe Eric will play an integral ...
... Primary and Key Secondary Endpoints -- CAPACITY 1 Misses ... Submit NDA and MAA -BRISBANE, Calif., Feb. 3 ... results from the two Phase 3 CAPACITY studies evaluating ... The primary endpoint of change in percent predicted Forced ...
... is like none other. To mark the observance, African ... promote science education, achievement motivation and positive psychological development among ... ... Washington, DC (PRWEB) February 3, 2009 -- African Ancestry, Inc., ...
Cached Biology Technology:Eric Lai Joins Gen-Probe as Senior Vice President, Research and Development 2InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 2InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 3InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 4InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 5InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 6InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 7InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 8InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 9InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 10InterMune Reports Results of Two Phase 3 CAPACITY Studies of Pirfenidone in IPF 11African Ancestry, Educators, Identity Experts Launch DNA Education Project during Historic Black History Month; 7th Graders Score High on Ultimate Self Test 2African Ancestry, Educators, Identity Experts Launch DNA Education Project during Historic Black History Month; 7th Graders Score High on Ultimate Self Test 3
(Date:10/15/2014)... has admitted Johannes Gutenberg University Mainz (JGU) as ... hub continues to maintain a significant nationwide standing ... "The acceptance of Johannes Gutenberg University Mainz as ... milestone in the national and international competition for ... of Rhineland-Palatinate can be proud that Mainz University ...
(Date:10/15/2014)... the 44th Rosenstiel Award for Distinguished Work in Biomedical ... the mechanisms of genomic instability and its implications for ... second alumnus to win the Rosenstiel Award; the first, ... Alt is the Charles A. Janeway Professor of Pediatrics ... an investigator at the Howard Hughes Medical Institute at ...
(Date:10/14/2014)... 2014)—It,s been millions of years since T. rex ... by Ohio University scientists is breathing life back into ... dinosaur snouts. The research has important implications for how ... to enhance the sense of smell and cool their ... Ohio University doctoral student Jason Bourke, lead author of ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... Bartness, Regents, Professor of Biology at Georgia State University, ... Institutes of Health to further research into the biological ... Research in Time (MERIT) award from the National Institute ... his lab,s investigation into the communication loop between fat ...
... new study suggests that it might be a genetic ... three thousand men - all pairs of male twins ... first time they had sex. Many participants in the ... and premature ejaculation at their first sexual encounter. These ...
... called a "Dream Team." Lombardi Comprehensive Cancer ... DSc, and 12 of the nation,s top breast cancer ... Stand Up To Cancer (SU2C) to form a scientific ... and brightest scientists will conduct new breast cancer research ...
Cached Biology News:Researcher garners major award from NIH for further exploration into the mechanisms of obesity 2Lombardi scientist brings 'dream team' breast cancer research effort to GUMC 2Lombardi scientist brings 'dream team' breast cancer research effort to GUMC 3
... BD Pathway 435 is an affordable, ... plates and slides, providing a broad ... system rapidly acquires high-resolution images with ... flexible computer-controlled excitation and emission filter ...
... include: Microarray hybridization chamber assembly (1 ... clamp, thumbscrew) Microarray chamber user guide ... intended to be cleaned and reused. The ... Catalog Oligo Microarray kits and all custom ...
... Blood Vessel Staining Kit is a very ... vascular endothelial cells, containing both anti-von Willebrand ... applicable to a variety of species. This ... for the staining of frozen and paraffin-embedded ...
... Coon's Modification of Ham's F-12 was ... produced by viral fusion. The modification consists ... and including ascorbic acid. The salt concentrations ... contains 0.863 mg zinc sulfate per liter, ...
Biology Products: