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Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep ,,, Technology

combination with orthogonal electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) probes has resulted in a dramatic reduction in API solvent ion noise and overall increased source robustness. Examples of increased robustness and solvent noise reduction in the full-scan MS mode when using Ion Sweep gas clearly illustrate the power of Ion Sweep technology that is now standard on both LCQ Deca XP Plus and LCQ Advantage platforms. Goal This report demonstrates the improvements in robustness and full-scan MS sensitivity observed when Ion Sweep technology is utilized. Both APCI and ESI techniques are examined. Several small molecules ranging from m/z 190900 were selected for APCI and ESI LC/MS assays to illustrate the improvement in full-scan performance of the API source using Ion Sweep technology. Repeated injections of alprazolam in plasma were performed to emphasize the robustness of the source when Ion Sweep is used. Experimental Conditions Surveyor MS Pump: 400 L/min
Surveyor Autosampler
Thermo Finnigan LCQ Deca XP Plus mass spectrometer with Ion Sweep Cap
Ion transfer tube temperature: 275-300C
APCI corona discharge current: 4.8 A (probe position: 2C)
ESI spray voltage: 5kV
(probe position: 3C)
Sheath gas: 45-65 au
Ion Sweep Gas: 10 au (using auxiliary gas line)
HPLC conditions: variable; see figure legends for details Figure 1: Picture of the Ion Sweep cap Discussion Theory
The Ion Sweep cap is shown in Figure 1. Nitroge
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