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Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep ,,, Technology

RohanA.Thakur, AndrewW. Guzzetta, and Julie A.Horner

Ion Trap Analysis

The data presented here can be acquired using a Thermo Finnigan LCQ Advantage, LCQ Deca XP, and Deca XP Plus ion trap mass spectrometer. Introduction Two important considerations in many LC/MS analyses are ruggedness and sensitivity. These two factors are important because analytes of interest are often present in complex matrices that can interfere with, suppress, or overwhelm the analyte signal.

In assays such as metabolite identification or peptide mapping, the full MS scan plays a pivotal role in setting up Data-Dependant MS/MS analyses. Information derived from the full MS scan triggers the sequence of events driven by the data-dependant set of parameters. Therefore, improvements in the quality of the full MS scan, such as increased signal-to-noise (S/N), make the resultant Data-Dependent acquisition more useful. Reducing API solvent ion noise, especially in the m/z 100-250 mass range, will enable Data-Dependent acquisitions for small molecules to be performed more efficiently on a per scan basis by lowering the number of nonsense full-scan MS/MS spectra. This reduction in the amount of MS/MS spectra acquired decreases data analysis time and increases the chances of finding elusive components in baseline noise.

Furthermore, metabolism and peptide samples inherently have matrices such as plasma or serum. Therefore, any analytical method used must have the ruggedness to withstand repeated analyses in these types of matrices.

Ion Sweep technology in
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