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ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System ,,, Target Validation and Identification of Novel Disease Indications

obal genomic perspective of target regulation can broaden the scope of discovery and lead to alternative, complementary, or possibly better targets for drug design. In aggregate, these data can be used to prioritize and validate gene targets for further therapeutic development.

ESR1 gene expression was observed in several normal human tissues, but to a much higher extent in female reproductive tissues. Disease-specific regulation of ESR1 gene expression was shown in breast and liver cancer, which largely confirms published observations. We extended ESR1 gene expression findings by demonstrating significant regulation in liver cirrhosis and in metabolic diseases (obesity and diabetes) in liver and skeletal muscle tissue. These data may be useful not only to confirm and validate ESR1 as a viable gene target in oncology, but also to consider ESR1 as a useful target or biological marker in other disease and therapeutic areas. The ASCENTA System provides a unique opportunity to gain access to comprehensive gene expression data which leads Figure 5 - Gene Family and Pathway Reports. These reports contain comprehensive information on how members of gene families and pathways are differentially regulated in human diseases. Reports contain descriptions, lists of annotated members as well as an aggregated Diff/X report which reveals gene regulation data for all members of the data set. to both an in-depth and broader understanding of how drug targets are expressed and regulated with respect to human disease.

References

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3. Liver Int. (2003) 23: 63-69.
4. Proc. Natl. Acad. Sci. USA (2000) 97:12729-12734.

For more information about Gene Logic's ASCENTA System, visit Gene Logic's web site at www.genelogic.com/solutions/ascenta and access the ASCENTA System
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