Navigation Links
ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System ,,, Target Validation and Identification of Novel Disease Indications

ARM1 (coactivator-associated arginine methyltransferase) methylates many proteins that modulate transcriptional regulation and is a coactivator of gene transcription for ESR1. Pelp1 (Proline-, glutamic acid-, leucine-rich protein 1) is a scaffold protein that may mediate the rapid cellular proliferation response transduced by ESR1 in response to estrogen binding. These pathways can be used as gene sets in the ASCENTA System to explore how they are regulated in the aforementioned oncology and metabolic disease therapeutic areas that display ESR1 regulation. These two pathway reports may provide new insight into the disease-specific gene expression modulation of ESR1 and related gene targets for followup studies.

These findings, combined with the pathway analysis for ESR1 seen in Figure 5, provide a global picture of ESR1 function in both normal biology and in human disease. This gene is clearly involved in cellular proliferation, transcriptional activation, and growth in response to steroid hormones. Regulation of this gene or other members of the cellular machinery with which it interacts can lead to abnormal growth conditions such as cancer. A broader understanding of the biological networks related to ESR1 function is easily obtained using the ASCENTA System. This global perspective may further facilitate the identification of additional pathways or gene families that could serve as alternative targets for novel disease therapeutics.

Conclusions

This Application Note demonstrates how the ASCENTA System can be used to quickly and easily examine expression levels of target genes, such as ESR1, across pre-selected tissue sample sets to determine where they are differentially regulated in hundreds of disease morphologies. In addition, the advanced analysis features of the ASCENTA System, such as pathway analysis, clearly demonstrate how a gl
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8

Related biology technology :

1. An Epitope Tagging Vector for Gene Expression in Mammalian Cells
2. Antibodies for Studying NMDA Receptor Protein Expression and Synapse-Specific Immunolabeling
3. High-Level Expression of Peanut Allergens Affected by Rare Codon Usage
4. Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in Mammalian Cells
5. Innovative Tissue Array Technology for High-Throughput Screening of Gene Expression
6. New Mammalian Expression Vectors Employ Stable, High-Level Fluorescence Humanized Renilla GFP Reporter
7. Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries
8. High-Level Protein Expression, One-Column Purification, and FLAG Epitope Tagging in E. coli
9. A New Lambda Vector for Mammalian Expression
10. Expression and Purification of Recombinant Proteins That Have Native Amino Acid Sequence
11. Codon Bias-Adjusted BL21 Derivatives for Protein Expression
Post Your Comments:
(Date:7/28/2014)... DC (PRWEB) July 28, 2014 It’s a ... GI Bill benefits to further their post-secondary education are failing ... a study released this year. And according to an analysis ... this shortfall is veteran students’ uninformed choice of college majors, ... The details of the study: Some 51.7 percent of post-9/11 ...
(Date:7/28/2014)... 28, 2014 Research and Markets has ... Market 2014-2018" report to their offering. ... is a technique used to determine the size of a ... is crucial to analyze the size of particles as it ... analysis is performed to determine the behavior and nature of ...
(Date:7/25/2014)... , July 25, 2014 Amgen (NASDAQ: ... Directors today declared a $0.61 per share dividend for ... paid on Sept. 5, 2014, to all stockholders of ... 14, 2014.  About Amgen Amgen is ... suffering from serious illnesses by discovering, developing, manufacturing and ...
(Date:7/25/2014)... According to a new market report ... Global Industry Analysis, Size, Share, Growth, Trends and Forecast, ... estimated at USD 161,056.5 million in 2014 and is ... 2014 to 2020, to reach an estimated value of ... market is witnessing a significant growth due to the ...
Breaking Biology Technology:Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Global Particle Size Analysis Market 2014-2018 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3
... /PRNewswire-Asia-FirstCall/  - China Cord Blood Corporation (NYSE: ... largest cord blood banking operator in China, today announced ... which allowed warrant holders to receive one ordinary share ... ordinary shares, equivalent to 2.2% of shares outstanding as ...
... BioTrends Research Group, Inc. finds that with ... (DMA) for the treatment of multiple sclerosis (MS), neurologists anticipate ... month after the launch of Gilenya, trial and uptake of ... to be tempered due to the perception that Extavia is ...
... December 9, 2010 Scientists from Pacific Biosciences of ... successfully employed single molecule, real-time (SMRT) DNA sequencing technology ... deadly cholera epidemic in Haiti. Published Thursday in ... results provide the first whole genome sequence analysis and ...
Cached Biology Technology:China Cord Blood Corporation Announces Completion of Warrant Exchange 2With the Recent Launch of Novartis's Gilenya, Extavia is Pushed Into the Background of Multiple Sclerosis Treatment One Year After its Launch 2With the Recent Launch of Novartis's Gilenya, Extavia is Pushed Into the Background of Multiple Sclerosis Treatment One Year After its Launch 3Pacific Biosciences and Harvard scientists decode genome of Haitian cholera pathogen 2Pacific Biosciences and Harvard scientists decode genome of Haitian cholera pathogen 3
(Date:7/27/2014)... and fungi can evade treatment by acquiring mutations in ... permanent mutations were once thought to be the only ... study has shown that microorganisms can use a temporary ... to gain the benefits of drug resistance without the ... a fungus called Mucor circinelloides, it is likely to ...
(Date:7/27/2014)... at Barts Cancer Institute have found that targeting a ... more effective, according to research published in Nature ... part of Queen Mary University of London, have found ... the body to repair itself after chemotherapy or radiotherapy, ... researchers removed FAK from blood vessels that grew in ...
(Date:7/27/2014)... 18,000 patients, scientists have identified more than two ... including six that had not been previously reported. ... was partially funded by the National Institutes of ... NIH laboratories. , "Unraveling the genetic underpinnings of ... involved in this complex disease, and hopefully, may ...
Breaking Biology News(10 mins):Scientists discover new, noncommittal mechanism of drug resistance 2Scientists discover new, noncommittal mechanism of drug resistance 3New drug target can break down cancer's barrier against treatment 2NIH scientists find 6 new genetic risk factors for Parkinson's 2
... laser laboratory operational later this year, he will use ... bonds like a stringed musical instrument. Tokmakoff, the ... at the University of Chicago in January to tackle ... vibrational spectroscopy methods that he has developed. "He ...
... Cognitive impairments are disabling for individuals with schizophrenia, ... affect a wide range of cognition, including memory, ... appear in the earliest stages of the disease ... Scientists are exploring a variety of strategies ...
... 2013 Shiner Beers, the popular Texas craft brew, will ... for Diabetes Research at the Translational Genomics Research Institute (TGen). ... kick off on Wednesday, March 13, at the Hotel San ... Conferences & Festivals. The noon-8 p.m. event, themed after ...
Cached Biology News:Watery research theme to flow through new Tokmakoff lab 2Watery research theme to flow through new Tokmakoff lab 3Tickling the brain with magnetic stimulation improves memory in schizophrenia 2Shiner Beers launches nationwide support of TGen diabetes studies 2
... Dithiothreitol DTT White solid.. ... disulfides to thiols, so reaction is "driven" to ... not contain waxy surfactant found in many other ... pentobarbitol. Purity: ≥97% by titration. ...
... This kit is designed for easy transformation ... protocol allows for successful transformation simply by ... reagents with cultured yeast cells. No complicated ... are required. The kit is particularly well ...
... for easy transformation of the budding yeast, ... transformation simply by mixing a plasmid DNA ... cells. No complicated steps, such as centrifugation ... is particularly well suited for high-throughput transformation ...
... pro balance increases your lab productivity and allows ... and regulatory compliance. Move ahead beyond traditional paper-based ... data system. *Instruments supported: ... MX, UMX, AG, XS, XP, PR, SR, PG-S, ...
Biology Products: