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ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System ,,, Target Validation and Identification of Novel Disease Indications

ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System
Target Validation and Identification of Novel Disease Indications

Introduction

ESR1 (Estrogen Specific Receptor 1) is a member of the nuclear hormone receptor (NHR) family. NHRs bind to steroid hormones in the cytoplasm, causing their translocation to the nucleus and increased affinity for transcriptional elements governing the expression of certain genes (1). NHRs activate genes leading to cell proliferation and differentiation, with the level of activity dependent on the target tissue. ESR1, also known as ER alpha, is up-regulated in Estrogen Receptor (ER)-positive breast cancers (2). Because steroid hormones can promote the growth of several types of malignancy, such as breast cancer, numerous drug companies have targeted ESR1 for development of antagonists. In this Application Note we examine ESR1 gene expression using Gene Logic's ASCENTA System and demonstrate how this tool can be used to reveal important expression characteristics of this drug target. This report not only confirms published gene expression results for female reproductive system and liver cancers, but also reveals novel findings of ESR1 expression in obesity and diabetes. These results both validate and expand the knowledgebase of ESR1 expression in human disease.

Materials and Methods

The ASCENTA System is a powerful and reliable gene expression database that contains over 8,000 well-characterized samples of normal and diseased tissues, expertly categorized into over 1300 sample sets. These sample sets have been created by Gene Logic's boardcertified pathologists. Samples undergo rigorous pathologic review to assure both their quality and the appropriateness of their inclusion in a particular sample set. Samples that meet pathologic criteria for in
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