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Discovery may halt progression of Alzheimer's

Jeff Johnson
Source: School of Pharmacy @ UW - Madison
In a finding that may cause a dramatic shift in the way scientists and researchers search for a therapy for Alzheimer's disease, a team of researchers led by Jeff Johnson, an associate professor at the
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"I said to myself, everybody is trying to kill neurons in mice to create the Alzheimer's pathology," he explains. "And here we have a mouse that has amyloid deposition and plaques yet no neurons are dying. Let's try to figure out why these mice aren't getting the disease."

The answer was surprising, and could completely alter the way researchers think about treating Alzheimer'......

Full article >>> " cut product has similar protective effects in human brain tissue in vitro. The latter finding is particularly significant.

"If we couldn't show that, we wouldn't have known if this protective mechanism is as relevant to humans as it was to mice," Johnson explains.

The next questionand it's a big oneinvolves developing a reliable method to deliver transthyretin into the brain, o......

Full article >>> d-brain barrier that can be used for Alzheimer's therapy. We'll find those molecules. They may already be out there, but nobody has looked at them in this context."

Johnson and Stein's research was and continues to be funded by the National Institute of Environmental Health Sciences. To view the report in full, visit
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'"/> By Aaron Conklin 09/13/04

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