Source: School of Pharmacy @ UW - Madison
In a finding that may cause a dramatic shift in the way scientists and researchers search for a therapy for Alzheimer's disease, a team of researchers led by Jeff Johnson
, an associate professor at the Full article >>>
"I said to myself, everybody is trying to kill neurons in mice to create the Alzheimer's pathology," he explains. "And here we have a mouse that has amyloid deposition and plaques yet no neurons are dying. Let's try to figure out why these mice aren't getting the disease."
The answer was surprising, and could completely alter the way researchers think about treating Alzheimer'......Full article >>>
" cut product has similar protective effects in human brain tissue in vitro. The latter finding is particularly significant.
"If we couldn't show that, we wouldn't have known if this protective mechanism is as relevant to humans as it was to mice," Johnson explains.
The next questionand it's a big oneinvolves developing a reliable method to deliver transthyretin into the brain, o......Full article >>>
d-brain barrier that can be used for Alzheimer's therapy. We'll find those molecules. They may already be out there, but nobody has looked at them in this context."
Johnson and Stein's research was and continues to be funded by the National Institute of Environmental Health Sciences
. To view the report in full, visit Full article >>>
Source:wistechnology.com By Aaron Conklin 09/13/04Related biology technology :1
. siRNA screening of the cell cycle with two dynamic GFP sensors (from Discovery Matters Issue 1, July 2005)2
. Exploiting the Life Science Data Explosion to Speed New Drug Discovery3
. Rapid, High Throughput Mutation Discovery Using Fluorescent SSCP on the ABI PRISM 3100 and 3100Avant Genetic Analyzers4
. Quantitation of Acrylamide in Food Samples on the Finnigan TSQ Quantum Discovery by LC/APCI-MS/MS5
. Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery6
. Document retention policy can get your arms around eDiscovery7
. Waisman director leading early stages of the Wisconsin Institutes for Discovery8
. WARF, UW-Madison seek designer for the Wisconsin Institutes for Discovery9
. GE announces first installation of Discovery VCT10
. Building commission approves Institutes for Discovery11
. Seven good reasons to approve the Institutes for Discovery