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Determination of N-nitrosamines in Baby Bottle Rubber Teats by Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry

trosoamine standard mixture were prepared. Calibration curves without the use of internal standards produced correlation coefficients for all standards > 0.998. Figure 2 shows the calibration curve for NMEA. Samples were obtained in methanol after extraction from the rubber teats. A 100 ppb spike of NDEA was added to each sample prior to extraction. Representative samples from the relatively clean synthetic polymer formulation (Figure 3) and the more contaminated natural rubber formulation (Figure 4) are shown below. Table 2 provides the nitrosamine concentrations observed for each of the polymer formulations.

Conclusions

A method for analyzing nitrosamines in baby bottle rubber teats is presented. This method offers an improvement over the current AOAC method in that LC/MS/MS offers more specificity without sacrificing sensitivity. The data from the analysis of the six samples indicates that the naturalrubber formulation had a higher concentration of NDMA and NMOR then either of the other two formulations. Also, it can be observed that the synthetic polymer formulation had on average less total nitrosamines then the silicone or the natural rubber samples. The calibration data for all samples indicates linearity down to 1 ppb. Replicate analysis of the NDEA spiked samples indicates that there are inconsistant recoveries of this nitrosamine. This is probably due to the formation of artifact nitrosamines during the extraction process.


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