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Determination of N-nitrosamines in Baby Bottle Rubber Teats by Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry

This application note illustrates an improved method to quantitate Nnitrosamines in baby bottle teats using APCI-MS. Six rubber nipple formulations were analyzed. Two formulations were composed of natural rubber, two were composed of a synthetic silicone polymer and the remaining two were composed of a synthetic polypropylene. The natural rubber formulations were found to have a significantly higher concentration of NDMA and NMOR compared to both the silicone and the polypropylene polymer formulations.

The presence of N-nitrosamines in baby bottle teats occurs due to the use of various dialkyl amines that are used as accelerators and stabilizers in the vulcanization process. These compounds have been shown to possess significant health risks upon infant ingestion. Current methodology for the analysis of nitrosamines in baby teats involves detection by GC/TEA.1 This method suffers from several drawbacks, the most significant being the inability to identify the peak of interest if another peak is coeluting or masking the analyte. A method is described for the determination of several N-nitrosamines that have been reportedly found in rubber baby bottle teats. They are: N-nitrosomethylethylamine (NMEA), N-nitrosodimethylamine (NDMA), N-nitrosodiethylamine (NDEA), N-nitrosomorpholine (NMOR), N-nitrosopiperidine (NPIP), and N-nitrosopyrrolidine (NPYR). Two samples from each of three different formulations were used to evaluate the level of nitrosamines in each. The first formulation is a synthetic polymer composed of polypropylene and a block copoloymer. The second formulation is a silicone polymer composed of vinyl, dimethyl, and methylvinyl siloxanes. The final sample is a natural rubber/isoprene polymer formulation.

Experimental conditions

The instrument used for analysis was the API 3000 LC/MS/MS System equipped with the Atmospheric Pressure Chemical Ionisation (APCI) source. Th
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