Navigation Links
Detection of N-in-1 Experiments: Extending the Range of N Using the API 3000 LC/MS/MS System

Purpose

Increased throughput in drug development laboratories can be obtained using the API 3000 LC/MS/MS System for N-in-1 experiments. Patented LINAC collision cell technology plays a key role in maximizing throughput by enabling faster scan times without sacrificing sensitivity.

Overview

A significant area in which LC/MS/MS has made an important impact is in N-in-1 studies (also referred to as cassette dosing or cocktail dosing) typically performed in pre-clinical pharmaceutical analyses. In these studies, several new chemical entities (NCEs) are administered simultaneously to a single animal, and their pharmacokinetic (PK) behavior is subsequently characterized. The advantages of cassette dosing include higher throughput of NCEs and fewer numbers of animals used. This results in overall greater screening efficiency and faster data attainment. However, combined drug interactions are always a concern in multiple dosing studies since you may obtain potentially misleading PK results. One remedy is to decrease the individual dose of each NCE. This alternative is made possible by the sensitivity and specificity of LC/MS/MS techniques.

Improved in instrument performance now makes it possible to decrease the total analysis time for NCEs. It is now possible to simultaneously and confidently detect many compounds in a single sample. The N-in-1 approach accelerates the drug discovery process and also reduces the cost of candidate screening. The API 3000 triple quadrupole LC/MS/MS System offers superior sensitivity and selectivity for the detection of compounds even at very low levels.

Key Features

Patented LINAC collision cell allows for faster scan rates without compromising data quality

Analyst software provides fast and easy data acquisition and reduction

Proven Turb
'"/>

Source:


Page: All 1 2 3

Related biology technology :

1. Simple, Sensitive, and Rapid Detection of FLAG -Tagged Fusion Proteins
2. A New PCR-based Mycoplasma Detection Method
3. HSVision Molecular Beacon Detection Module Rapidly Detects Herpes Simplex Virus DNA
4. Detection and Identification of Phosphorylation Sites in Proteins Using LC/MS/MS with Neutral Fragment Loss Mapping
5. Detection of mRNAs on Cryosections of the Cardiovascular System Using DIG-Labeled RNA Probes
6. Gene Expression Arrays: Highly Sensitive Detection of Expression Patterns with Improved Tools for Target Amplification
7. The DIG System Nonradioactive and Highly Sensitive Detection of Nucleic Acids
8. Quantitative Measurement of Cell Proliferation Using the BrdU ELISA: A Comparison Between Colorimetric and Chemiluminescent Detection
9. Quantification of Nucleosomes in Serum by the Cell Death Detection ELISAplus
10. A Further Step in Understanding Apoptosis Direct Detection of PARP Cleavage
11. In Situ Cell Death Detection Kit
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Detection Experiments Extending the Range Using the API System

(Date:10/20/2014)... 20, 2014 The report “Pharmacy ... Systems, Packaging and Labeling Systems, Table-top Counters) by ... Global Forecasts & Trends to 2019” analyzes and ... in North America, Europe, Asia-Pacific, and the Rest ... tables and 30 figures spread through 300 pages ...
(Date:10/20/2014)... 20, 2014 Convey Computer , ... team from Iowa State University won first place in ... a Convey HC-2ex, the team’s solution achieved the highest ... than the second place finisher. , Experts from all ... the month long challenge, using a variety of design ...
(Date:10/20/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... orders to $5.8 million and provides a good start to Q4.  ... North America and one in the Middle ... at record levels," said Peter Bruijns , President & CEO. ... of Q3 than they have been for any complete year since ...
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... Horovitz , Ph.D., from its board of directors effective on ... August 2003, and served as its chairman from June 2006 ... the Nominating and Corporate Governance and Audit Committees of the ... than a decade of dedicated service to GenVec, and its ...
Breaking Biology Technology:Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2
... with Capital Data, Inc. , an independent ... according to TeraMEDICA's executive vice president, Paul Schmelzer. ... TeraMEDICA's TI2m archive solution into its own enterprise ... includes Wisconsin, Minnesota, North Dakota, South Dakota, Iowa, ...
... organization? Any temper tantrums lately? Or an adolescent episode ... maybe just a bit of flagging memory? , ,Given ... time or another, it's easy to begin thinking about ... always wisdomas they age. It's even understandable to want ...
... Watts Wacker, hippie extraordinaire and rock-star futurist, spoke at ... week. I was floored by his insights and had ... Watts offered, along with some R-squared commentary: , ,Watts: ... Paulone of JC's disciplesfinally laid down, there were 200,000 ...
Cached Biology Technology:TeraMEDICA and Capital Data enter into diagnostic imaging agreement 2Aging IT 2Aging IT 3Watts Up 2
(Date:10/16/2014)... at William and Mary,s Virginia Institute of Marine ... the Environmental Protection Agency to identify the streams ... to develop tools to help local governments and ... depends critically on a dataset of tidal-marsh observations ... Only with this historical baseline can today,s researchers ...
(Date:10/16/2014)... infections and worldwide claims the lives of 160,000 ... University have succeeded in developing a promising vaccination ... , Xavier Saelens (VIB/UGent): "We discovered a new ... development of a novel approach to vaccination against ... small children and elderly people." , RSV: ...
(Date:10/15/2014)... As our ability to assess the pandemic risk from ... developments, we must not allow ourselves to become complacent ... an international consortium of scientists. , Influenza pandemics arise ... have yet to develop widespread immunity – spreads in ... in the past 100 years, the worst of which ...
Breaking Biology News(10 mins):EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3New perspectives for development of an RSV vaccine 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... brain develops, neurons reach out helter-skelter forming new connections, ... the brain chooses which connections to keep and which ... branches have the most electrical activity—a finding that could ... , The work, published in the April 21 issue ...
... specialized subpopulation of the antibody-producing B cells of the ... kinds of immunity -- innate and acquired, Duke University ... between B-1a and B-1b cells they have uncovered offers ... of vaccines, they said. , B cells are the ...
x...
Cached Biology News:Speak up: Louder neurons form more connections 2Specialized immune-system B cells play double-barreled role 2Specialized immune-system B cells play double-barreled role 3