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Detection of N-in-1 Experiments: Extending the Range of N Using the API 3000 LC/MS/MS System

Purpose

Increased throughput in drug development laboratories can be obtained using the API 3000 LC/MS/MS System for N-in-1 experiments. Patented LINAC collision cell technology plays a key role in maximizing throughput by enabling faster scan times without sacrificing sensitivity.

Overview

A significant area in which LC/MS/MS has made an important impact is in N-in-1 studies (also referred to as cassette dosing or cocktail dosing) typically performed in pre-clinical pharmaceutical analyses. In these studies, several new chemical entities (NCEs) are administered simultaneously to a single animal, and their pharmacokinetic (PK) behavior is subsequently characterized. The advantages of cassette dosing include higher throughput of NCEs and fewer numbers of animals used. This results in overall greater screening efficiency and faster data attainment. However, combined drug interactions are always a concern in multiple dosing studies since you may obtain potentially misleading PK results. One remedy is to decrease the individual dose of each NCE. This alternative is made possible by the sensitivity and specificity of LC/MS/MS techniques.

Improved in instrument performance now makes it possible to decrease the total analysis time for NCEs. It is now possible to simultaneously and confidently detect many compounds in a single sample. The N-in-1 approach accelerates the drug discovery process and also reduces the cost of candidate screening. The API 3000 triple quadrupole LC/MS/MS System offers superior sensitivity and selectivity for the detection of compounds even at very low levels.

Key Features

Patented LINAC collision cell allows for faster scan rates without compromising data quality

Analyst software provides fast and easy data acquisition and reduction

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