Navigation Links
Detection of Morphine and Morphine-Glucuronide in Saliva or Urine with a Rapid and Simple Method Without Derivatization on the Varian 500-MS

oid caused (usually) by a high concentration of salt eluting from the LC column.

Conclusion

This application note demonstrates the picogram detection, without derivatization, of morphine and its metabolite morphine-glucuronide in saliva or urine. The limit of quantitation for these analytes is well within the limits set by NIDA and SAMHSA for the detection of opiates in saliva and/or urine. More importantly, this method does not require the lengthy and often tedious derivatization as required in a GC/MS method. All compounds were found to be linear in the calibration range tested and all had very good correlation coefficients (average r2= 0.989).

Finally, this application demonstrates the use of two useful features of the 500-MS, the use of the built-in 6-port injection valve and the syringe pump. Together they can be used as a diverter valve to avoid potential damage to the electrospray interface by diverting salts away from the source and applying a make-up volume of solvent for maintaining optimum spray conditions.

References

1. NIDA InfoFacts Sept. 2004 (www.drugabuse.gov)

2. US Dept. Of Justice Bureau of Justice Statistics (www.ojp.usdoj.gov/bjs/dcf/du.html)

3. DEA Briefs and Background, Drugs and Drug Abuse www.usdoj.gov/dea/concern/morphine.html


'"/>

Source:


Page: All 1 2 3 4

Related biology technology :

1. Simple, Sensitive, and Rapid Detection of FLAG -Tagged Fusion Proteins
2. A New PCR-based Mycoplasma Detection Method
3. HSVision Molecular Beacon Detection Module Rapidly Detects Herpes Simplex Virus DNA
4. Detection and Identification of Phosphorylation Sites in Proteins Using LC/MS/MS with Neutral Fragment Loss Mapping
5. Detection of mRNAs on Cryosections of the Cardiovascular System Using DIG-Labeled RNA Probes
6. Gene Expression Arrays: Highly Sensitive Detection of Expression Patterns with Improved Tools for Target Amplification
7. The DIG System Nonradioactive and Highly Sensitive Detection of Nucleic Acids
8. Quantitative Measurement of Cell Proliferation Using the BrdU ELISA: A Comparison Between Colorimetric and Chemiluminescent Detection
9. Quantification of Nucleosomes in Serum by the Cell Death Detection ELISAplus
10. A Further Step in Understanding Apoptosis Direct Detection of PARP Cleavage
11. In Situ Cell Death Detection Kit
Post Your Comments:
(Date:7/27/2015)... 27, 2015 IDEXX Laboratories, Inc. (NASDAQ: ... have submitted over 100,000 specimens to IDEXX Reference Laboratories ... first 10 days since the breakthrough kidney function test ... a leading cause of suffering and death in cats ... consistent with generally accepted kidney disease prevalence data showing ...
(Date:7/24/2015)... ... July 24, 2015 , ... VetStem Biopharma, proudly announces a new long ... cell therapy training and clinical opportunities. , “We are very excited to be able ... San Diego area. Stem cell therapy is an established treatment for arthritic conditions in ...
(Date:7/24/2015)... 2015 The global next ... 27.8 billion by 2022, growing at an estimated CAGR ... new study by Grand View Research, Inc. Development of ... result in significant reduction in cost of sequencing one ... usage rates of next generation sequencing throughout the forecast ...
(Date:7/23/2015)... ... 23, 2015 , ... Science and technology continue to improve all aspects of ... – according to Susan Chang, MD, director of the Division of Neuro-oncology at UC ... technology are impacting the development of new treatments and advancing strategies to minimize treatment ...
Breaking Biology Technology:Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 2Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 3Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 4Over 100,000 Pets Tested with New IDEXX SDMA Kidney Function Test Since Product Launch on July 13 5VetStem Biopharma, proudly announces a new long term partnership with VCA Emergency Animal Hospital & Referral Center. 2VetStem Biopharma, proudly announces a new long term partnership with VCA Emergency Animal Hospital & Referral Center. 3Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 2Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 3Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 4Next Generation Sequencing (NGS) Market To Reach $27.8 Billion By 2022: Grand View Research, Inc. 5Experts Present How Science and New Technology are Driving New Brain Tumor Treatments and Improving Quality of Life 2Experts Present How Science and New Technology are Driving New Brain Tumor Treatments and Improving Quality of Life 3
... Catalyst,Pharmaceutical Partners, Inc. (Nasdaq: CPRX ) today ... months ended June 30, 2008., "We continue ... stated Patrick J. McEnany, Catalyst,s Chief Executive Officer.,"In ... in our U.S.,Phase II clinical trials evaluating CPP-109 ...
... TAIAN CITY, Shandong, China, Aug. 14 /Xinhua-PRNewswire-FirstCall/ --,China ... Biologic,",the "Company"), one of the leading plasma-based pharmaceutical ... reported financial results,for the second quarter ended June ... -- Revenues increased 35.1% year-over-year to $11.9 ...
... 14 /Xinhua-PRNewswire-FirstCall/ --,China-Biotics, Inc. (OTC Bulletin Board: CHBT) ... the manufacture,research, development, marketing and distribution of probiotics ... quarter of its 2009,fiscal year, ended June 30, ... -- Net sales increased 19.5% year-over-year to $11.4 ...
Cached Biology Technology:Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 2Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 3Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 4Catalyst Pharmaceutical Partners Reports Second Quarter 2008 Financial Results 5China Biologic Products Reports Second Quarter 2008 Results 2China Biologic Products Reports Second Quarter 2008 Results 3China Biologic Products Reports Second Quarter 2008 Results 4China Biologic Products Reports Second Quarter 2008 Results 5China Biologic Products Reports Second Quarter 2008 Results 6China Biologic Products Reports Second Quarter 2008 Results 7China Biologic Products Reports Second Quarter 2008 Results 8China Biologic Products Reports Second Quarter 2008 Results 9China Biologic Products Reports Second Quarter 2008 Results 10China Biologic Products Reports Second Quarter 2008 Results 11China Biologic Products Reports Second Quarter 2008 Results 12China Biologic Products Reports Second Quarter 2008 Results 13China Biologic Products Reports Second Quarter 2008 Results 14China Biologic Products Reports Second Quarter 2008 Results 15China-Biotics, Inc. Reports First Quarter 2009 Financial Results 2China-Biotics, Inc. Reports First Quarter 2009 Financial Results 3China-Biotics, Inc. Reports First Quarter 2009 Financial Results 4China-Biotics, Inc. Reports First Quarter 2009 Financial Results 5China-Biotics, Inc. Reports First Quarter 2009 Financial Results 6China-Biotics, Inc. Reports First Quarter 2009 Financial Results 7China-Biotics, Inc. Reports First Quarter 2009 Financial Results 8China-Biotics, Inc. Reports First Quarter 2009 Financial Results 9China-Biotics, Inc. Reports First Quarter 2009 Financial Results 10China-Biotics, Inc. Reports First Quarter 2009 Financial Results 11
(Date:7/21/2015)... July 21, 2015 Today, ZTE announced its ... as well as expected revenues in 2015 that relate to sales ... revenue guidance of approximately 2,200 MSEK for 2015. Jörgen ... leading smartphone manufacturer in China and we ... 02 5 for Axon , ...
(Date:7/21/2015)... , July 21, 2015 Passwords ... as seen in the recent U.S. Office of ... solution to the infosec conundrum, but developers and ... stored. To address this dilemma, Biometrics-as-a-Service provider HYPR ... Biometric Tokenization SDK for third party integration. ...
(Date:7/13/2015)... Calif. , July 13, 2015 ... developer of human interface solutions, today announced sampling ... touch and display driver integration (TDDI) product targeting ... the first to combine Synaptics , best-in-class ... proven display driver technology developed in the company,s ...
Breaking Biology News(10 mins):FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4Synaptics Announces Sampling of Second Generation TDDI Solutions 2Synaptics Announces Sampling of Second Generation TDDI Solutions 3
... Chicago have been awarded more than $12 million by the ... acquired and familial causes of heart failure -- with the ... The five years of new funding supports an ongoing ... and head of physiology and biophysics at UIC, that looks ...
... Oil and water don,t mix, but add in some ... team of UCLA chemists and engineers has developed a new ... are both transparent and electrically conductive. Their method involves the ... this solution is sufficiently agitated it spreads over virtually any ...
... PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ... financial results on Wednesday, November 10, 2010 after the markets close. ... p.m. Eastern Time to discuss the financial results.   ... conference call via phone, please dial (866) 271-5140 from the United ...
Cached Biology News:$12 million grant to probe root causes of heart failure 2Radically simple technique developed to grow conducting polymer thin films 2Radically simple technique developed to grow conducting polymer thin films 3PDL BioPharma to Announce Third Quarter 2010 Financial Results on November 10, 2010 2
... system uses three Adept CE 4100 high pressure ... in one microlitre increaments. The Adept CE ... System control and data processing is provided by ... 4900., Column heater/chillers can be supplied. ...
... The excellent isocratic refractive index chromatography system, ... CE 4700. Data processing is provided ... delivery is by the high pressure CE 4100 ... can be supplied. The system can ...
Narrow-mouth has heavy-duty rim. Approximate graduations are in durable white enamel. Extra large marking space. capacity 125 mL Special grade: student grade...
...
Biology Products: