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Detection of Alprazolam and Temazepam in a Bovine Plasma Matrix Using the Varian 500-MS Ion Trap Mass Spectrometer

compounds in all of the matrices studied, over the calibration range of 0.2 pg/μL 1000 pg/μL (1 pg 5000 pg on column). An LOQ = 0.2 pg/μL (1 pg on column) was determined for all three matrix conditions for both Alprazolam and Temazepam.

Even with the addition of the matrix, the range of quantitation did not change. Figure 3 shows the extracted ion chromatogram (m/z = 255.2) of Temazepam in all three of the matrix conditions.

It is evident from Figure 3 that the 500-MS Ion Trap is capable of handling a biological matrix and thus is still able to reach a low level of detection under the conditions described. These results show that the 500-MS Ion Trap is a sensitive and quantitative tool for the detection of target analytes in biological matrices.

Conclusion

The measurements taken with Alprazolam and Temazepam spiked into bovine plasma matrix illustrate that it is possible to reach low levels of quantitation (low- to sub-pg level) using the 500-MS Ion Trap Mass Spectrometer. Quantitative analysis of Temazepam and Alprazolam in a biological matrix has been demonstrated in the 500-MS instrument illustrating its excellent performance in both quantitative and qualitative analysis.


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