Chemical Stability of the Brinkmann Bottletop Dispenser
and the Brinkmann Bottletop Buret
Bottletop dispensers are used in the lab for dispensing a wide range of
different solvents from glass or stainless steel containers. These dispensers
have to meet various requirements. For example, they must not give off any
substances which may disturb trace analysis, have cytotoxic properties,
distort optical tests or influence chromatographic methods and residue analysis.
Even after prolonged contact with the solvent, the materials of the dispenser
must not be affected nor bind the solvent non-specifically. This means
that there are very high demands on the chemical resistance of bottletop
dispensers.
The Brinkmann Bottletop Dispenser and Brinkmann ChemSaver Bottletop
Dispenser are made of material which is particularly resistant to chemicals.
Only parts made of PFA (perfluor alkoxy), PTFE (polytetrafluor ethylene),
boron silicate glass 3.3 and platinum / iridium come into contact with
the solvents. The adapter rings for the screw connection are made of PP
(polypropylene).
The following pages include an example on the use of a Bottletop Dispenser
for residue analysis in the lab of a food manufacturer as well as a list
of the materials of which the Bottletop Dispenser is made and their chemical
resistence.
Dispensing ultrapure solvents for residue analysis at the Hipp plant
in Pfaffenhofen, Germany
The residue analysis of foodstuffs places high demands on the solvents
and the inertness of the lab equipment used to detect, for example, even
the smallest traces of pesticides.
Therefore, contamination caused by lab equipme
dle width="13%">3 / 3 *1
Cresol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2 *1 |
Cupric sulphate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Decahydronaphtalene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Dibutyl phtalate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2 *1 |
Dichlorobenzene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Dichlorethane (Ethy
l dichloride)*5
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Dichlormethane (Methylene chloride)*5
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Diethylene glycol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Diethyl ether |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Dimethylformamide |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 3 *1 |
1.4-Dioxan |
1 / 1 |
1 / 1
1 / 1 |
1 / 1 |
2 / 2 *1 |
Ethanol 100% (Ethyl alcohol) |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Ethyl acetate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Ethylene oxide |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Formaldehyde, 40% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Formic acid, 98-100% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Fuel oil |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Glycerol *4 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Glycol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
n-Hexane |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Hydrochloric acid 35% *5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Hydrochloric acid 37% *5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 3 *1 |
Hydrofluoric acid, 40% |
1 / 1 |
1 / 1 |
3 / 3 |
3 / 3 |
1 / 1 |
Hydrogen peroxide, 30% *3 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 |
1 / 1 |
Iodine-Potassium iodide sol. |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Isobutanol (Isobutyl alcohol) |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Isopropanol (Isopropyl alcohol) |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1
Isopropyl benzene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Lactic acid / Lactate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Magnesium chloride (MgCl) |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Mercury |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Mercury (I) chloride |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Methanol (Methyl alcohol) *5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Methyl propyl ketone |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2 *1 |
Nitric acid, 10% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Nitric acid, 50% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Nitric acid, 70% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Nitrobenzene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Octane / iso octane |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Oil of turpentine |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Oxalic acid |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Pentane (n- / Iso-) *5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Perhlorethylene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Perchloric acid, 10% |
1 / 2 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 3 *1 |
Phenol, 100% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Phosphoric acid, 85% |
1 / 1 |
1 / 1 |
2 / 3 |
2 / 3 |
1 / 1 |
Potassium chloride |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Potassium hydroxide , 50% |
1 / 1 |
1 / 1 |
1 / 2 |
1 / 2 |
1 / 1 |
Potassium permanganate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Propanol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Propylene glycerol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Propylene oxide |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Pyridine |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2 *1 |
Salicylaldehyde |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Salicylic acid |
1 / 1 |
A series of experiments were performed to test the suitability of the
Bottletop Dispenser for food analysis. Aim: to determine whether the Bottletop
Dispenser is inert to the solvents commonly used in this field.
Two examples of these experiments are described briefly below:
Test A
100 ml of the solvent acetonitrile (CH3CN) were drawn from a larger
supply with a Bottletop Dispenser, evaporated in a rotation evaporator
and then dissolved in 1 ml of the solvent i-octane. This sample
was examined using gas Chromatography.
Result: No other peak could be found in addition to the solvent
peak. Therefore, no substances had been released from the Bottletop
Dispenser.
Test B
A specific amount of the herbicide atrazine (50 pg / ml) 1) was
added to a sample treated as in test A as a comparative standard
for pesticides. In order to detect minute amounts of pesticide,
the background in the chromato-gram must consistently be as low
as possible.
Result: The atrazine peak can be clearly seen in the chromatogram
without any ghost bands. This shows that minute amounts of pesticides
can be detected with this system.
1) (EG drinking water limit: 100 pg / ml) signal time solvent peak A signal
time solvent peak B Atrazine peak
For each chemical, 2 figures are stated. The figure on the left is stability
at a test temperature of +20C, t
align=middle width="13%">1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Scintillation cocktail |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Silver acetate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Silver nitrate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Sodium acetate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Sodium dichromate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Sodium hydroxide, 50% |
1 / 1 |
1 / 1 |
1 / 2 |
1 / 2 |
1 / 1 |
Sulphuric acid, 60% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Sulphuric acid, 98% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Tartaric acid |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Tenside (Tween-, Trition X-, Brij-dilutions) |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Tetrachloroethylene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Tetrahydrofuran |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Toluene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Trichloroacetic acid, 10% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Trichloroethane |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Trichloroethylene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Trichlorofluorethane *5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Tricloromethane (Chloroform) *5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2 |
2 / 2 *1 |
Triethylene glycol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Trifluoroacetic acid (fuming; strongest of halogenized
acids)*5 |
3 / 3 |
1 / 1 |
3 / 3 |
3 / 3 |
3 / 3 |
Tripropylenglycol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Urea |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Vinylidene chloride |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Xylene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Zinc chloride, 10% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Zinc sulphate, 10% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
*1 PTFE adapter available
*2 Pt-Ir can be easily loosened from the srping
*3 catalytic reaction with Pt-Ir spring
*4 Liquid with high viscosity
*5 Liquid with high vapor pressure; gases leak (observe safety regulations)
Materials
Part
Bottletop Dispenser
ChemSaver Bottletop Dispenser
Bottletop Buret
Direct contact to dipensing fluid
Valve block
PFA
PFA
PFA
Valve cock
PTFE
PTFE/PFA
Filling valve
ETFE
ETFE
ETFE
Discharge valve
ETFE
ETFE/PFA
ETFE/PFA
Discharge valve
PFA
PFA
PFA
Spring for valve
Pt-Ir
Pt-Ir
Valve ball
Borosilicate (DURAN)
Borosilicate (DURAN)
Borosilicate (DURAN)
Cylinder
Borosilicate (DURAN)
Borosilicate (DURAN)
Borosilicate (DURAN)
Telescopic filling tube
FEP
FEP
FEP
Indirect contact to dipensing fluid
Piston (2.510 ml)
PFA
PFA
PTFE/PFA
Piston (25100 ml)
ETFE
ETFE
Piston holder
PP
PP
PTFE
Cylinder casing
PP
PP
PTFE/PFA
Protective cylinder sleeve
PTFE
PTFE
Valve block housing
PP
PP
PP
Discharge tube sleeve
PP
PP
PP
Discharge tube cap
PVDF
Air vent cup
PP
PP
PP
Volume adjustment knob
PP
PP
O-ring for valve cock protection
Viton
Viton
Viton
Volume setting knob
PP
PP
Discharge valve toggle
PP
PP
PP
Drying tube
PP
PP
PP
Wheel
PP
Display foil
PE
DURAN
Borosilicate 3.3
PE
Polyethylene
ETFE
Tefzel ETFE (Ethylene tetrafluorethylene)
PTFE
Polytetrafluoroethene
FEP
Teflon FEP (Tetrafluoroethylene perfluoropropylene)
PVDF
Polyvinylidene fluoride
PFA
Teflon PFA (Perfluoro-alkoxy-PTFE-Copolymer)
Pt-Ir
Platinum-Iridium
PP
Polypropylene
he figure on the right is the stability
at +50C. Salts were tested as almost saturated solutions. All data
are recommondations without guarantee. 1 = resistant 2 = sensitive (raw
material is affected after longer contact) 3 = incompatible
CHEMICALS |
PFA |
PTFE |
Boron silicateglass 3.3 |
Bottletop Buret & Dispenser can
be used |
PP Adapter rings |
Acetaldehyde |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 3 *1 |
Acetic acid, 50% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Acetone *5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Acetonitrile *5 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Acrylonitrile |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Adipic acid |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Allyl alcohol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Aluminum chloride |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Aluminum hydroxide |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Amino acids |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Ammonia |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Ammonium chloride |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Ammonium hydroxide, 30% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
n-Amyl acetate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Amyl alcohol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Amyl chloride |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Aniline |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Aqua regia *2 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 3 *1 |
Barium chloride (BaCl2) |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Benzaldehyde |
1 / 2 |
1 / 1 |
1 / 2 |
1 / 1 |
1 / 1 |
Benzene |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 2 *1 |
Benzine |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2 *1 |
Benzyl alcohol |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Biuret reagent |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Boric acid |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Bromine |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Bromoform (Tri Methanbromid) |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
n-Butanol
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
n-Butyl acetate |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2 *1 |
Calcium chloride |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Carbon disulphide |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Carbon tetrachloride |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
3 / 3 *1 |
Chloroacetic acid |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Chromic acid, 10% |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
Chromic acid, 50% *2 |
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
2 / 2 *1 |
Chromic sulfuric acid, concentrated *2
|
1 / 1 |
1 / 1 |
1 / 1 |
1 / 1 |
| '"/>
Source:
Page: All 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26
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