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Chemical Stability of the Brinkmann Bottletop Dispenser ,,, and the Brinkmann Bottletop Buret

Chemical Stability of the Brinkmann Bottletop Dispenser and the Brinkmann Bottletop Buret

Bottletop dispensers are used in the lab for dispensing a wide range of different solvents from glass or stainless steel containers. These dispensers have to meet various requirements. For example, they must not give off any substances which may disturb trace analysis, have cytotoxic properties, distort optical tests or influence chromatographic methods and residue analysis.

Even after prolonged contact with the solvent, the materials of the dispenser must not be affected nor bind the solvent non-specifically. This means that there are very high demands on the chemical resistance of bottletop dispensers.

The Brinkmann Bottletop Dispenser and Brinkmann ChemSaver Bottletop Dispenser are made of material which is particularly resistant to chemicals. Only parts made of PFA (perfluor alkoxy), PTFE (polytetrafluor ethylene), boron silicate glass 3.3 and platinum / iridium come into contact with the solvents. The adapter rings for the screw connection are made of PP (polypropylene).

The following pages include an example on the use of a Bottletop Dispenser for residue analysis in the lab of a food manufacturer as well as a list of the materials of which the Bottletop Dispenser is made and their chemical resistence.

Dispensing ultrapure solvents for residue analysis at the Hipp plant in Pfaffenhofen, Germany

The residue analysis of foodstuffs places high demands on the solvents and the inertness of the lab equipment used to detect, for example, even the smallest traces of pesticides.

Therefore, contamination caused by lab equipment has to be avoided under all circumstances.

A series of experiments were performed to test the suitability of the Bottletop Dispenser for food analysis. Aim: to determine whether the Bottletop Dispenser is inert to the solvents commonly used in this field.

Two examples of these experiments are described briefly below:


Test A

100 ml of the solvent acetonitrile (CH3CN) were drawn from a larger supply with a Bottletop Dispenser, evaporated in a rotation evaporator and then dissolved in 1 ml of the solvent i-octane. This sample was examined using gas Chromatography.
Result: No other peak could be found in addition to the solvent peak. Therefore, no substances had been released from the Bottletop Dispenser.

Test B

A specific amount of the herbicide atrazine (50 pg / ml) 1) was added to a sample treated as in test A as a comparative standard for pesticides. In order to detect minute amounts of pesticide, the background in the chromato-gram must consistently be as low as possible.
Result: The atrazine peak can be clearly seen in the chromatogram without any ghost bands. This shows that minute amounts of pesticides can be detected with this system.

1) (EG drinking water limit: 100 pg / ml) signal time solvent peak A signal time solvent peak B Atrazine peak

For each chemical, 2 figures are stated. The figure on the left is stability at a test temperature of +20C, the figure on the right is the stability at +50C. Salts were tested as almost saturated solutions. All data are recommondations without guarantee. 1 = resistant 2 = sensitive (raw material is affected after longer contact) 3 = incompatible

CHEMICALS PFA PTFE Boron silicateglass 3.3 Bottletop Buret & Dispenser can be used PP Adapter rings
Acetaldehyde 1 / 1 1 / 1 1 / 1 1 / 1 1 / 3 *1
Acetic acid, 50% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Acetone *5 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Acetonitrile *5 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Acrylonitrile 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Adipic acid 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Allyl alcohol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Aluminum chloride 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Aluminum hydroxide 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Amino acids 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Ammonia 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Ammonium chloride 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Ammonium hydroxide, 30% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
n-Amyl acetate 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Amyl alcohol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Amyl chloride 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Aniline 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Aqua regia *2 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Barium chloride (BaCl2) 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Benzaldehyde 1 / 2 1 / 1 1 / 2 1 / 1 1 / 1
Benzene 1 / 1 1 / 1 1 / 1 1 / 1 1 / 2 *1
Benzine 1 / 1 1 / 1 1 / 1 1 / 1 2 / 2 *1
Benzyl alcohol 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Biuret reagent 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Boric acid 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Bromine 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Bromoform (Tri Methanbromid) 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1

n-Butanol

1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
n-Butyl acetate 1 / 1 1 / 1 1 / 1 1 / 1 2 / 2 *1
Calcium chloride 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Carbon disulphide 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Carbon tetrachloride 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Chloroacetic acid 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Chromic acid, 10% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Chromic acid, 50% *2 1 / 1 1 / 1 1 / 1 1 / 1 2 / 2 *1
Chromic sulfuric acid, concentrated *2 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Cresol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 2 *1
Cupric sulphate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Decahydronaphtalene 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Dibutyl phtalate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 2 *1
Dichlorobenzene 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Dichlorethane (Ethyl dichloride)*5 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Dichlormethane (Methylene chloride)*5 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Diethylene glycol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Diethyl ether 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Dimethylformamide 1 / 1 1 / 1 1 / 1 1 / 1 1 / 3 *1
1.4-Dioxan 1 / 1 1 / 1 1 / 1 1 / 1 2 / 2 *1
Ethanol 100% (Ethyl alcohol) 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Ethyl acetate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Ethylene oxide 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Formaldehyde, 40% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Formic acid, 98-100% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Fuel oil 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Glycerol *4 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Glycol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
n-Hexane 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Hydrochloric acid 35% *5 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Hydrochloric acid 37% *5 1 / 1 1 / 1 1 / 1 1 / 1 1 / 3 *1
Hydrofluoric acid, 40% 1 / 1 1 / 1 3 / 3 3 / 3 1 / 1
Hydrogen peroxide, 30% *3 1 / 1 1 / 1 1 / 1 3 / 3 1 / 1
Iodine-Potassium iodide sol. 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Isobutanol (Isobutyl alcohol) 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Isopropanol (Isopropyl alcohol) 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Isopropyl benzene 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Lactic acid / Lactate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Magnesium chloride (MgCl) 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Mercury 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Mercury (I) chloride 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Methanol (Methyl alcohol) *5 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Methyl propyl ketone 1 / 1 1 / 1 1 / 1 1 / 1 1 / 2 *1
Nitric acid, 10% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Nitric acid, 50% 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Nitric acid, 70% 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Nitrobenzene 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Octane / iso octane 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Oil of turpentine 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Oxalic acid 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Pentane (n- / Iso-) *5 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Perhlorethylene 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Perchloric acid, 10% 1 / 2 1 / 1 1 / 1 1 / 1 1 / 3 *1
Phenol, 100% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Phosphoric acid, 85% 1 / 1 1 / 1 2 / 3 2 / 3 1 / 1
Potassium chloride 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Potassium hydroxide , 50% 1 / 1 1 / 1 1 / 2 1 / 2 1 / 1
Potassium permanganate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Propanol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Propylene glycerol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Propylene oxide 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Pyridine 1 / 1 1 / 1 1 / 1 1 / 1 2 / 2 *1
Salicylaldehyde 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Salicylic acid 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Scintillation cocktail 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Silver acetate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Silver nitrate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Sodium acetate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Sodium dichromate 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Sodium hydroxide, 50% 1 / 1 1 / 1 1 / 2 1 / 2 1 / 1
Sulphuric acid, 60% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Sulphuric acid, 98% 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Tartaric acid 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Tenside (Tween-, Trition X-, Brij-dilutions) 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Tetrachloroethylene 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Tetrahydrofuran 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Toluene 1 / 1 1 / 1 1 / 1 1 / 1 2 / 3 *1
Trichloroacetic acid, 10% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Trichloroethane 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Trichloroethylene 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Trichlorofluorethane *5 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Tricloromethane (Chloroform) *5 1 / 1 1 / 1 1 / 1 1 / 2 2 / 2 *1
Triethylene glycol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Trifluoroacetic acid (fuming; strongest of halogenized acids)*5 3 / 3 1 / 1 3 / 3 3 / 3 3 / 3
Tripropylenglycol 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Urea 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Vinylidene chloride 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Xylene 1 / 1 1 / 1 1 / 1 1 / 1 3 / 3 *1
Zinc chloride, 10% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
Zinc sulphate, 10% 1 / 1 1 / 1 1 / 1 1 / 1 1 / 1
*1 PTFE adapter available
*2 Pt-Ir can be easily loosened from the srping
*3 catalytic reaction with Pt-Ir spring
*4 Liquid with high viscosity
*5 Liquid with high vapor pressure; gases leak (observe safety regulations)

Materials

Part Bottletop Dispenser ChemSaver Bottletop Dispenser Bottletop Buret Direct contact to dipensing fluid Valve block PFA PFA PFA Valve cock PTFE PTFE/PFA Filling valve ETFE ETFE ETFE Discharge valve ETFE ETFE/PFA ETFE/PFA Discharge valve PFA PFA PFA Spring for valve Pt-Ir Pt-Ir Valve ball Borosilicate (DURAN) Borosilicate (DURAN) Borosilicate (DURAN) Cylinder Borosilicate (DURAN) Borosilicate (DURAN) Borosilicate (DURAN) Telescopic filling tube FEP FEP FEP Indirect contact to dipensing fluid Piston (2.510 ml) PFA PFA PTFE/PFA Piston (25100 ml) ETFE ETFE Piston holder PP PP PTFE Cylinder casing PP PP PTFE/PFA Protective cylinder sleeve PTFE PTFE Valve block housing PP PP PP Discharge tube sleeve PP PP PP Discharge tube cap PVDF Air vent cup PP PP PP Volume adjustment knob PP PP O-ring for valve cock protection Viton Viton Viton Volume setting knob PP PP Discharge valve toggle PP PP PP Drying tube PP PP PP Wheel PP Display foil PE DURAN Borosilicate 3.3 PE Polyethylene ETFE Tefzel ETFE (Ethylene tetrafluorethylene) PTFE Polytetrafluoroethene FEP Teflon FEP (Tetrafluoroethylene perfluoropropylene) PVDF Polyvinylidene fluoride PFA Teflon PFA (Perfluoro-alkoxy-PTFE-Copolymer) Pt-Ir Platinum-Iridium PP Polypropylene
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