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Cenix-Designed siRNAs for 95% of Human and Mouse Genomes

ective, Cenix Designed siRNAs
High quality siRNA is just one aspect of a successful gene silencing experiment. The design of the siRNA sequence is also critical. Ambion has partnered with Cenix BioSciences, which has developed a proprietary siRNA design algorithm that has been refined over the past year to yield an extremely high percentage of effective siRNA sequences (see Designing a Better siRNA). Figure 2 in that article demonstrates the high success rate of the algorithm. In a test of 79 siRNAs designed using the algorithm, 94% (74 of 79) reduced target mRNA levels by at least 70% when assayed 48 hours after transfection. You can now order siRNAs to your gene of interest that have been pre-designed using this algorithm. Multiple designs are immediately available for >95% of all human, mouse, and rat genes listed in the public RefSeq database maintained by NCBI. Ambion and Cenix are committed to continual refinements of the algorithm and corresponding updates to the pre-designed sequences as more is learned about siRNA design and as the RefSeq database is updated.


Complete Flexibility -- Choose One, Two or Three Pre-designed siRNAs Per Gene
To offer you the greatest flexibility in your research, you can have pre-designed siRNAs made at various synthesis scales, with your choice of purification method. Although a single pre-designed siRNA sequence has a high
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Related biology technology :

1. Silencer Validated siRNAs
2. Five Ways to Produce siRNAs
3. Efficient Delivery of siRNAs to Human Primary Cells: Electroporation vs. Chemical Transfection
4. IMPROVE SILENCING SUCCESS: siRNAs THAT WORK BETTER!
5. Optimizing Chemical Transfection and Electroporation of siRNAs
6. Delivering siRNAs to Difficult Cell Types
7. Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success
8. Deliver siRNAs Into Primary Cells
9. Optimize Transfection of siRNAs for RNAi
10. RNAi as a Tool for Mammalian Gene Analysis: Applications of siRNAs
11. Test More siRNAs for Less
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