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Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

Pre-miR miRNA Precursor Molecule. The protein expression of two oncogenes that were predicted to be regulated by the cancer-related miRNA was measured by immunofluorescence. Transfection of the cancer-related Pre-miR miRNA Precursor Molecule resulted in a greater than 2-fold decrease in the expression of the proteins from both oncogenes. (B) An Anti-miR miRNA Inhibitor targeting the same cancer-related miRNA was introduced into cells that express high levels of the miRNA. Immunofluorescence 48 hours after transfection revealed an approximately two-fold increase in the expression of both oncogenes.


Conclusions

miRNA expression studies in cancer patient samples suggest that at least a few miRNAs are key regulators of cellular processes that control unencumbered cell proliferation in humans. Based on target site prediction and validation of two targets of these miRNAs, it appears that misregulation of these key miRNAs could participate in cancer progression by failing to regulate the expression of one or more oncogenes.


Scientific Contributors
David Brown, Jaclyn Shingara, Kerri Keiger, Jeffrey Shelton, Kathy Lew, Brian Cannon, Sean Banks, Steve Wowk, Mike Byrom, Angie Cheng, Xiaowei Wang, Emmanuel Labourier Ambion, Inc.


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