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Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform

hoimager analysis.


miRNA Expression in Colon Cancer

Twenty-five tumor and NAT samples from colon cancer patients were analyzed using the miRNA array platform. Like the lung cancer comparisons, the various miRNAs were clustered based on their relative expression in tumors across the different colon cancer patients (Figure 1B). Five miRNAs (miR-143, -145, -195, -130a, and -331) were expressed at significantly lower levels in the tumors of more than 70% of the patients. Four miRNAs (miR-223, -21, -17, and -106) were expressed at significantly higher levels in the tumors of more than 70% of the patients.


miRNAs as Cancer Markers

It is interesting that eight different miRNAs were differentially expressed between the tumor and normal adjacent samples for most of the lung and colon patient samples that we analyzed (Figure 3). These same miRNAs were also found to be differentially expressed in the breast, thymus, bladder, pancreatic, and prostate cancer patients that we analyzed, suggesting that these miRNAs might control cellular processes that when altered lead to cancer.

Figure 3. Differentially Expressed miRNAs in Multiple Cancer Types. miRNA array analysis comparing tumor and normal adjacent tissues from patients with various types of cancer was used to identify miRNAs that are differentially expressed in cancer. The percentage of patients exhibiting up- or down-regulation of a given miRNA was calculated for each cancer type. The eight that were most often differentially expressed a
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