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Cancer-Related miRNAs Uncovered by the mirVana miRNA Microarray Platform


Ambion has developed a complete line of research tools for the analysis of microRNAs (miRNAs). Recently, we introduced the mirVana miRNA microarray platform (consisting of the mirVana miRNA Labeling Kit and the mirVana miRNA Probe Set) and several miRNA tools for interrogating miRNA function and identifying miRNA target sites (Pre-miR miRNA Precursor Molecules, Anti-miR miRNA Inhibitors, and the pMIR-REPORT miRNA Expression Reporter Vector). In this article, these new tools are used to identify and characterize potential effectors of cancer progression.

Figure 1. miRNA Expression in Lung and Colon Cancer Patients. The miRNA expression profiles of tumor vs normal adjacent tissues were compared for lung (A) and colon (B) cancer patients. The miRNAs are provided in rows; the patients are presented in columns. Green in the heat map shows miRNAs that are down-regulated in the tumor sample relative to the normal adjacent tissue sample, and red shows miRNAs that are up-regulated in the tumor sample relative to the normal adjacent tissue sample.


miRNA Expression in Cancer Samples

miRNAs are small, siRNA-like molecules encoded in the genomes of animals and plants that regulate gene expression through sequence-specific interactions with target mRNAs. More than 200 miRNAs have been identified in humans, and many of the miRNA genes are located at chromosomal fragile sites associated with cancer [1]. Studies of miRNA expression profiles in cancer samples have identified a handful of miRNAs that are differentially regulate
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