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Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine ,,, in Bovine Plasma using the TSQ Quantum Mass Spectrometer

pg/L
Figure 4d: Plasma spiked at 0.5 pg/L LC/MS/MS Chromatograms of Bovine Plasma Spiked with Paroxetine and Internal Standard Quality Control samples at 0.3 and 25 pg/L Figure 5a: Quality Control at 0.3 pg/L

Figure 5b: Quality Control at 25 pg/L Results The chromatography (Figure 4a4d and 5a5b) was capable of resolving Paroxetine and De-Fluoro-Paroxetine from any matrix peaks and was suitable for the quantitation of unknowns.

A calibration curve was constructed from the first and eighth replicate set of calibration standards (Figure 6). The linear fit calibration curve, weighted 1/X, of area ratio plotted against concentration was used to calculate the concentrations of all calibration standards and quality control samples throughout the analytical batch.

A correlation coefficient of r2=0.9994 with an equation of Y=0.00346891 +0.0312025*x was obtained for the curve.

The internal standard peak area response was 3.1% cv for 121 injections (Figure 7). Figure 6: Paroxetine/Int Std area ratio

Figure 7: Internal Standard area response The calibration curve was used to calculate the values of the eight replicates at each level of quality control sample (Table 1) and of the remaining six replicates of standards (Table 2). Table 1: Intra-batch accuracy and precision
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