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Assess the In Vivo Activation of Signal Transduction Pathways with,,,PathDetect Reporting Systems

which is convenient, sensitive, and quantitative. The plasmids included in the PathDetect reporting systems are highly purified, functionally tested, and transfection ready; all plasmids can be purchased separately.

Pathway

Transcriptional Activator

PathDetect System

Plasmids available

JNK (c-Jun N-Terminal Kinase)

c-Jun

PathDetect c-Jun Trans-Reporting System

pFA2-cJun plasmid
pFC-MEKK plasmid

MAPK (Mitogen-Activated Protein Kinase)
and JNK

Elk1

PathDetect Elk1 Trans-Reporting System

pFA2-Elk1 plasmid
pFC-MEK1 plasmid

PKA
(Cyclic AMP-Dependent Protein Kinase)

CREB

PathDetect CREB Trans-Reporting System

pFA2-CREB plasmid
pFC-PKA plasmid

p38 MAP Kinase

CHOP

PathDetect CHOP Trans-Reporting System

pFA-CHOP
pFC-MEK3

Uncharacterized pathway

c-Fos

pFA-cFos

Uncharacterized pathway

ATF2

pFA-ATF2

REFERENCES
  1. Karin, M. and Hunter, T. (1995) Curr. Biol. 5: 747-757.

  2. Boulikas, T. (1995) Crit. Rev. Eukaryot. Gene Expr. 5: 1-77.

  3. Wingender, E. (1990) Crit. Rev. Eukaryot. Gene Expr. 1: 11-48.

  4. Treisman, R. (1996) Curr. Opin. Cell Biol. 8: 205-215.

  5. Xu, L., S
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FGF Receptor 1 Antibody...
Immunogen: Purified native p24 from strain IIIB. Storage: -20 C, Avoid Freeze/Thaw Cycles...
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