Navigation Links
Antibodies for Studying NMDA Receptor Protein Expression and,,,Synapse-Specific Immunolabeling

New antibodies for neuroscience research


Danny Q. Hoang Michael Browning Xinping Yang Peter Pingerelli
Stratagene Cloning Systems, Inc.


Stratagene introduces affinity purified antibodies for NMDA receptor subunits that are useful for studying expression of the NR2A, NR2B and NR2C subunit proteins in different cell types and brain regions. These antibodies have been used in Western blot analysis of rat brain to study expression of specific NMDA receptor subunits. In addition, these antibodies can be used for immunoprecipitation and immunohistochemistry. Stratagene also introduces an antibody for synapsin I, the synapse-specific protein, that is useful for studying synaptogenesis and synapse elimination.

Glutamate is a major excitatory neurotransmitter in the mammalian central nervous system. The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). The NMDAR plays a critical role in long-term potentiation (LTP), a putative cellular substrate of memory.1 This receptor has also been linked to conditions involving injury neurotoxicity and in pathological states, such as epilepsy and Parkinsons, Huntingtons and Alzheimers diseases.2

Molecular cloning studies indicate that five NMDA receptor genes exist, including NMDAR1 (NR1) and four NR2 subunits (NR2A-D).3 When reconstituted in vitro, the functional properties of neuronal NMDAR appear to be conferred by the combination of an NR1 subunit with any of the four NR2 subunits.4 In addition, there are a number of different splice variants of the N
'"/>

Source:


Page: All 1 2 3 4

Related biology technology :

1. Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies
2. Optimizing Transfection Conditions for Studying Signal Transduction Pathways
3. Enzyme Immunoassay for Studying Intracellular Levels of cAMP
4. New Reporter Plasmids for Studying Interferon-Stimulated Signal Transduction Pathways
5. New Fusion Trans-Activator Plasmids for Studying Signal Transduction Pathways
6. Detecting Gastrin-Releasing Peptide Receptor by in situ PCR on Archived Tissue
7. pFB-ERV: Retroviral Delivery of the Ecdysone Receptor Proteins
8. Gene-Specific Primers for NMDA Receptor Subunits
9. TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins
10. Quantification of the Purinergic Receptor P2X3 using ICAT and Orthogonal 2D LC-MS/MS with an Ion Trap Mass Spectrometer
11. Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A
Post Your Comments:
(Date:4/28/2015)... The Pistoia Alliance, a global, not-for-profit alliance of ... to innovation in R&D, has announced the start of ... Mapping project has been set up to create better ... life sciences R&D. The project will see the Pistoia ... services to enable the universal application of ontologies. , ...
(Date:4/28/2015)... 28, 2015 According to a 2013 ... patients receive medical treatment from burn injuries per year. ... injury, extensive formation of scars with subsequent contractures remains ... for which there is no adequate treatment. Contractures are ... movement and can cause permanent deformity. , Synedgen ...
(Date:4/28/2015)... Reproductive endocrinologist Dr. Kaylen Silverberg , ... battling infertility in this country, testified on behalf of ... first state in the nation to consider creating a clearinghouse ... who desire to receive them. , Infertility affects over 7.3 ... is one of the few medical diseases that is curable, ...
(Date:4/27/2015)... HEIDELBERG , Alemania, April 27, 2015 ... un nuevo receptor utilizando tecnología de descubrimiento de biomarcador ... en el tratamiento de millones de pacientes con cáncer ... que ha recibido una patente en Europa titulada "Tissue ... de Molecular Health de que EPHB4 es un nuevo ...
Breaking Biology Technology:Pistoia Alliance Announces Start of Ontologies Mapping Project 2Synedgen Burn Treatment Results Presented at Premier Wound Conference 2Synedgen Burn Treatment Results Presented at Premier Wound Conference 3Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 2Texas Fertility Center Supports a Groundbreaking HB1145 that Facilitates Embryo Donation in Texas 3Molecular Health obtiene la patente para un nuevo receptor 2Molecular Health obtiene la patente para un nuevo receptor 3
... definitive agreement with Elan Pharmaceuticals, Inc. (a subsidiary of Elan Corporation, plc) ( ELN) ("Elan") to acquire the analgesic therapy, PRIALT(R) (ziconotide intrathecal infusion). , ... , ... ... ...
... March 11 /PRNewswire/ - Trillium Therapeutics Inc. (TTI), ... it has entered into two definitive license agreements with University ... in Toronto, Ontario , granting Trillium exclusive worldwide rights ... stem cell transplantation and cancer. , ...
... President and Chief Executive Officer of Neurocrine Biosciences, will be presenting at the Roth 22nd Annual OC Growth Conference in Laguna Niguel . , ... , ... ... ...
Cached Biology Technology:Azur Pharma Announces the Signing of a Definitive Agreement to Acquire PRIALT(R) From Elan 2Azur Pharma Announces the Signing of a Definitive Agreement to Acquire PRIALT(R) From Elan 3Azur Pharma Announces the Signing of a Definitive Agreement to Acquire PRIALT(R) From Elan 4Azur Pharma Announces the Signing of a Definitive Agreement to Acquire PRIALT(R) From Elan 5Azur Pharma Announces the Signing of a Definitive Agreement to Acquire PRIALT(R) From Elan 6Trillium expands immunology pipeline and enters stem cell field through in-licensing of two new programs 2Trillium expands immunology pipeline and enters stem cell field through in-licensing of two new programs 3Neurocrine Biosciences to Present at the Roth 22nd Annual OC Growth Conference 2
(Date:4/20/2015)... April 20, 2015 Huntington Memorial Hospital is ... implant a new miniaturized, wireless monitoring sensor to manage ... first and only FDA-approved heart failure monitoring device that ... used by physicians to manage heart failure. ... implanted in the pulmonary artery (PA) during a non-surgical ...
(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, ... for the 2015 New York Design Awards under the ... New York City Design Awards are part of a ... over 2,500 ratings from the marketplace, industry and judging ...
(Date:4/9/2015)... 9, 2015 Synaptics Inc. (NASDAQ: SYNA ), ... that it will report financial results for the third ... after the close of market. The company will host ... 2:00 p.m. PT (5:00 p.m. ET), during which management ... on the live call, analysts and investors should dial ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2
... by two Queens scientists has resulted in an exciting new ... chemical weapons and pesticides. Recently completed testing by an ... be greater than 99 per cent effective when used on ... tested in solution, full destruction of all three agents was ...
... genetic modification (GM) and RNA Interference are being deployed ... series of European and global initiatives. The ground was ... that exploit these technologies at a recent workshop organised ... highlighted the interlocking themes underlying the debate over livestock ...
... in molecular targeting, translational cancer research and cancer ... 17,000 scientists from around the world gather at ... the 2008 Annual Meeting of the American Association ... the meeting will include late-breaking clinical trial findings ...
Cached Biology News:Queen's develops safe 'green' decontamination method 2Europe develops new technologies to boost health of livestock 2Europe develops new technologies to boost health of livestock 3AACR annual meeting showcases developments in understanding and targeting cancers 2AACR annual meeting showcases developments in understanding and targeting cancers 3
...
...
...
Sold individually or included in the MasterAmp™ PCR Optimization Kit without ammonium sulfate. Includes dNTPs, buffer, and varying amounts of MgCl2 and the MasterAmp™ PCR Enhancer (with be...
Biology Products: