Navigation Links
Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using ,,, an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier ,,, Software Package

7 shows the experimental MS2 spectra of the three impurities after correlation with the fragment ions predicted by Mass Frontiers Fragments & Mechanisms module. Mass Frontiers predictions were based on the chemical structures proposed for each of the three impurities displayed in Figure 3. As in Figure 6, the experimental MS2 peaks that corresponded to fragment ions predicted by Mass Frontier are colored in red. The observation that all of the major peaks in the experimental MS2 spectra of the impurities are colored red clearly supports the validity of the proposed structures.

Table 1 summarizes the results of the correlation between Mass Frontiers fragmentation predictions and the experimental MS2 spectra that are used to verify the structures proposed for the impurities in Figure 3. In order to understand how this is done, it is important to recognize that except for the substitution site (colored in red in Figures 1 and 3), the proposed structures of the drug intermediate and the three impurities are identical. Therefore, if the experimental MS2 spectra of the four compounds each possess a fragment ion at m/z values that Mass Frontier assigns to the same mechanism of formation if the structures proposed for the three impurities are correct:

The fragment ion should have the same m/z value in all four experimental MS2 spectra if the Mass Frontier predicted mechanism of formation produces a fragment structure that does not contain the substitution site.

The fragment ion should have experimental m/z values differing by the mass of the substituents if the Mass Frontier predicted mechanism of formation produces a fragment structure that does contain the substitution site (i.e. if the fragment ion has a m/z value of M in the drug intermediates exper
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9

Related biology technology :

1. Practical Applications of HyperDSC in a Pharmaceutical Laboratory
2. World Class Life Science and Pharmaceutical Companies Leverage DoveBid s Global Reach for Asset Management and Disposition
3. Low Abundance cDNA Cloned Using Stratagenes Human Universal cDNA Library
4. Oil-Free PCR Using the Hot Top Assembly
5. Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries
6. Signal Transduction Reporting Systems Using Cis-Acting Enhancer Elements
7. Using XL1-Red Mutator Strain to Generate Esterase Variants
8. Detect Released Oligosaccharides Using the Eagle Eye II Still Video Imaging System
9. Comparison of Growth Techniques and Media for the Purpose of Plasmid Isolation from E. coli Using the Eppendorf Perfectprep Plasmid Mini Kit
10. Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood Mini Kit
11. Genomic DNA Extraction from Buffy Coat Using the Perfect gDNA Blood Mini Kit
Post Your Comments:
(Date:10/1/2014)... 2014 The U.S. Department of Labor ... University Edwardsville as part of the Trade Adjustment Assistance ... is co-administered by the Department of Labor and Department ... Labor Thomas E. Perez and Secretary of Education Arne ... training grants to nearly 270 colleges across the country. ...
(Date:9/30/2014)... news release is available in German . ... the Technische Universitt Mnchen (TUM) have demonstrated a new ... experiments show that future computer chips could be based ... As the main enabling technology of the semiconductor industry ... limits, the TUM researchers and collaborators at the University ...
(Date:9/30/2014)... YORK , Sept. 30, 2014 ... to kill nematodes. Nematodes are microscopic parasitic roundworms, ... water, and inside other plants and animals. Nematicides ... volatility or other properties promoting migration through the ... more than 1,000 plant-parasitic nematodes. With more than ...
(Date:9/30/2014)... Fla. , Sept. 30, 2014 CORD:USE ... pleased to announce that it has entered into an ... Inc. (Tianhe) which has licensed a series of patented technologies ... cells for possible clinical applications.  Tianhe is performing Phase ... and Spain using Tianhe,s Stem ...
Breaking Biology Technology:U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 2CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 3CORD:USE is Pleased to Announce it has Partnered with Tianhe Stem Cell Biotechnologies, Developer of Cord Blood Stem Cell Therapy Showing Promising Results in Clinical Trials for the Treatment of Diabetes and Autoimmune Diseases 4
... NEW YORK, Jan. 7 Aisling Capital announced today ... its newest life sciences fund, Aisling Capital III, LP. ... companies developing pharmaceutical, biopharmaceutical and medical products, as well ... other important services to the healthcare industry. With a ...
... 7 Codexis, Inc. today announced,a licensing agreement with ... product, using a proprietary Codexis,biocatalyst. Teva, the largest ... of this generic product. The product is one ... States. , Under the agreement, ...
... , - Most Comprehensive ... Ansell Healthcare, a global leader in barrier ... showcasing the most recent offerings at,the Arab Health fair ... 6 Booth E10).,Ansell invites healthcare workers to discover its ...
Cached Biology Technology:Aisling Capital Announces Close of US$650M Life Sciences Fund 2Codexis, Teva in Licensing Agreement Final 2Managing Risk Through Quality: Ansell Healthcare's Innovative Gammex(R) Glove Range on Display at Arab Health 2009 2
(Date:9/30/2014)... New England Journal of Medicine reports positive results ... crizotinib against the subset of lung cancer marked by ... of 50 patients with advanced non-small cell lung cancer ... was 72 percent, with 3 complete responses and 33 ... takes for the disease to resume its growth after ...
(Date:9/30/2014)... involving mice and published in the October 2014 issue ... , suggests that just because you can do it, ... of Italian scientists have found that using marijuana in ... system. This damage may result in autoimmune diseases and ... disease and rheumatoid arthritis in adulthood. , "I hope ...
(Date:9/30/2014)... is available in German . ... behavioural response to risky situations such as exposure to ... now found in a long-term study on different populations ... metabolic rate and ambient temperature. High metabolic rates and ... in these scenarios birds were more likely to approach ...
Breaking Biology News(10 mins):NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2Adolescent exposure to thc may cause immune systems to go up in smoke 2Risky metabolism 2
... Science University (OHSU) and Intel Corp. are teaming ... the field of personalized medicine by dramatically increasing ... patient,s individual genetic profile. Through a multi-year research ... from the two institutions will develop hardware, software ...
... new tool to search for more effective medications and new ... catalogue the entire set of lightweight, carbon-containing molecules that chemists ... has more than 10^60 (that,s 1 with 60 zeroes after ... of the world,s problems have molecular solutions in this chemical ...
... today, a special issue of the Philosophical Transactions ... a major challenge facing our society: feeding a global ... capita food consumption, while preventing widespread ecological and social ... Scientist at The Woods Hole Research Center (WHRC) and ...
Cached Biology News:OHSU teams with Intel to decode the root causes of cancer and other complex diseases 2OHSU teams with Intel to decode the root causes of cancer and other complex diseases 3OHSU teams with Intel to decode the root causes of cancer and other complex diseases 4OHSU teams with Intel to decode the root causes of cancer and other complex diseases 5Scientists map all possible drug-like chemical compounds 2Scientists map all possible drug-like chemical compounds 3Ecology, economy and management of an agro-industrial Amazon frontier 2Ecology, economy and management of an agro-industrial Amazon frontier 3
Phosphotyrosine IgG mouse monoclonal antibody: Alkaline Phosphatase conjugate...
Rabbit polyclonal to GPCR G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
... has been developed for use with ... of nonspecific background staining due to ... blocking peroxidase with hydrogen peroxide. ... combination with additional novel components to ...
Rabbit polyclonal to Wilms Tumor Protein ( Abpromise for all tested applications). entrezGeneID: 7490 SwissProtID: P19544...
Biology Products: