Navigation Links
Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using ,,, an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier ,,, Software Package

Mark R. Kagan1, Julian Phillips2, Carrie Liu3

1Thermo Finnigan, Piscataway, NJ;
2Thermo Finnigan, San Jose, CA;
3Eisai Research Institute, Andover, MA

Chemical Structure Validation

The data presented here can be acquired using the Thermo Finnigan LCQ Series of ion trap mass spectrometers

Introduction

With the high cost of bringing new drugs to market, the number of candidates a pharmaceutical company can develop is limited. Most are using increasingly sophisticated screening techniques to eliminate poor candidates early in the discovery process. To be successful, properties such as the adsorption, distribution, metabolism, excretion and toxicity of compounds, their metabolites and impurities must be assessed quickly and accurately to characterize potential lead compounds.

High-throughput analysis of impurities is particularly challenging at the low sample concentrations typical in biological matrices. The wide range of possible modifications further complicates data interpretation. With inherent high sensitivity, selectivity, and sophisticated Data Dependent operational capabilities, the Thermo Finnigan LCQ Series of ion trap mass spectrometers are well suited for applications involving impurities.

Rapid acquisition, interpretation and analysis of structural data is crucial for maintaining a compound screening process capable of working in a combinatorial environment. Mass Frontier, Thermo Finnigans pioneering software package for interpretation and management of mass spectra, can be configured to automatically predict fragmentation pa
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9

Related biology technology :

1. Practical Applications of HyperDSC in a Pharmaceutical Laboratory
2. World Class Life Science and Pharmaceutical Companies Leverage DoveBid s Global Reach for Asset Management and Disposition
3. Low Abundance cDNA Cloned Using Stratagenes Human Universal cDNA Library
4. Oil-Free PCR Using the Hot Top Assembly
5. Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries
6. Signal Transduction Reporting Systems Using Cis-Acting Enhancer Elements
7. Using XL1-Red Mutator Strain to Generate Esterase Variants
8. Detect Released Oligosaccharides Using the Eagle Eye II Still Video Imaging System
9. Comparison of Growth Techniques and Media for the Purpose of Plasmid Isolation from E. coli Using the Eppendorf Perfectprep Plasmid Mini Kit
10. Genomic DNA Extraction from Buccal Swabs Using the Perfect gDNA Blood Mini Kit
11. Genomic DNA Extraction from Buffy Coat Using the Perfect gDNA Blood Mini Kit
Post Your Comments:
(Date:1/15/2014)... Westlake Village, Calif. (PRWEB) January 15, 2014 ... cancer treatment and management through the genomic analysis of ... will offer Therapy Finder™, a web-based cancer decision support ... a reporting option with Cynvenio’s ClearID™ genomic test, Therapy ...
(Date:1/15/2014)... 15, 2014 More than 5 million ... 1 in 3 seniors will die with Alzheimer’s or ... jaw-dropping figures have shocked many Americans into looking for ... prevent these tragic age-related cognitive disorders. Jonathan Weisman, president ...
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ., ... announced that Lupin Limited, one of India’s top five ... Protégé PharmD System for high throughput solid form ... focused on a wide range of quality, affordable generic ...
(Date:1/14/2014)... Diego, CA (PRWEB) January 14, 2014 ... on the products of cells grown under simulated embryonic ... international license agreement with Suneva Medical, Inc. for physician-dispensed ... (CCM). , This agreement is an amendment ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... On June 27, 2008,GeneraMedix Inc. received approval ... its Epoprostenol for Injection 1.5 mg New Drug,Application ... indicated for the long-term,intravenous treatment of primary pulmonary ... of disease in NYHA,Class III and Class IV ...
... Advanced Life Sciences,Holdings, Inc. (Nasdaq: ... the,discovery, development and commercialization of novel drugs ... respiratory diseases, today,announced that it was added ... Investment Group reconstituted its comprehensive set of ...
... July 3 Senesco,Technologies, Inc. ("Senesco" or the ... has contracted with Polyplus-transfection (Illkirch, France) to,supply Polyplus,s ... of siRNA against Factor 5A and a plasmid ... reported positive preclinical in vivo results,using its combination ...
Cached Biology Technology:GeneraMedix Inc. Receives Approval for Epoprostenol for Injection 1.5 mg 2Advanced Life Sciences Added to Russell Microcap Index 2Advanced Life Sciences Added to Russell Microcap Index 3Senesco Signs a Supply Agreement for Polyplus-transfection's Delivery System 2Senesco Signs a Supply Agreement for Polyplus-transfection's Delivery System 3Senesco Signs a Supply Agreement for Polyplus-transfection's Delivery System 4
(Date:4/24/2014)... study of animal intelligence to-date finds that animals with bigger ... week in the journal Proceedings of the National Academy ... history of research aimed at understanding the animal mind. Specifically, ... and use tools, read social cues, or even understand basic ... of animal intelligence have focused on only one or a ...
(Date:4/24/2014)... the largest river turtle in North America, weighing in ... century. Now researchers from Florida and the University of ... but three. , Examining museum specimens and wild ... ancient reptile. , Once heavily hunted for turtle meat ... Turtle Soup in the 1960s the riverine populations ...
(Date:4/23/2014)... of bioethics experts have added "playwright" to their resumes ... grappling with an onslaught of ethical issues as genomic ... human genome was first sequenced. , Until now ... Bush have been performed for, and by, their peers ... meetings and in classrooms. With Oxford University Press, ...
Breaking Biology News(10 mins):Animals with bigger brains, broader diets have better self control 2Animals with bigger brains, broader diets have better self control 3Two new US turtle species described 2Two new US turtle species described 3Bioethicists use theatrical narratives to bridge the gap between society and science 2Bioethicists use theatrical narratives to bridge the gap between society and science 3
... the forests of Thailand have given conservationists confirmation that ... to the Wildlife Conservation Society. The footagetaken ... Forest Complex over the last yearhas revealed a cornucopia ... elephants, gaurs, sun bears, and many other species. The ...
... studying a unique collection of human skulls have shown ... occurred independently through separate evolutionary events may have actually ... Manchester and Barcelona examined 390 skulls from the Austrian ... skull is highly integrated, meaning variation in one part ...
... News media registration opened today for the American ... the largest scientific conferences of the New Year. The meeting ... and will take place at the San Diego Convention Center ... presentations on new discoveries that span science,s horizons from ...
Cached Biology News:Candid video clips from Thailand show anti-poaching efforts saving wildlife 2Human skull study causes evolutionary headache 2
...
Smac/DIABLO (CT) - IgG for Western Blotting, Host: Rabbit Family: Smac/DIABLO...
Mouse monoclonal [ICRF 44] to Integrin alpha M...
... The new Finnpipette Focus Long ... cone for pipetting from test ... narrow and long necked vessels. ... whatever volume you select, it ...
Biology Products: