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Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module

Key words: Micronucleus assays • toxicology • image analysis • IN Cell Analyzer


Micronucleus induction is a key characteristic of genotoxic compounds and analysis of micronuclei formation resulting from DNA strand breakage (clastogens) or interference with chromosome segregation (aneugens) is an important component of toxicology screening of new drug candidates. Manual scoring of micronucleus assays is time consuming and subject to operator variance, bias, and error while automated analysis of micronucleus assays is significantly faster and enables consistently objective scoring.

This application note describes the use of the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module for automated scoring of micronucleus assays.


Materials
Products used
IN Cell Analyzer 3000 25-8010-11

IN Cell Analyzer 3000 Seat License* 63-0055-97

IN Cell Analyzer 1000 25-8010-26

IN Cell Analyzer 1000 Seat License* 25-8098-22

Micronuclei Formation Analysis Module† 28-4047-13

IN Cell Translator Image Converter 28-4047-40


Other materials required
CHO-KI cells (ATCC or ECACC
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