Navigation Links
Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

ameters.

The other algorithm that Metabolite ID provides for searching for unexpected metabolites is the Correlation Search. This search compares all of the MS2 spectra in a selected data file with the MS2 spectrum of the parent drug specified in the Parent Drug List Manager dialog box. The MS2 spectra are compared based on intensities and masses. The correlation score is a measure of the overlap between the MS2 spectra of a potential metabolite and the reference scan.

The results of a correlation search of the verapamil monkey microsome incubation data file are shown in Figure 5. The table at the left gives the results in terms of Parent M/Z, RT (min), and Correlation. The top chromatogram on the right-hand side is the Modification Summary. It sums together the extracted ion chromatograms of all of the modifications specified in the Modification List Manager dialog box. The second chromatographic trace in Figure 5 is the Correlation Summary. It sums together the correlation score of every MS2 scan in the specified data file. The mass spectrum in the middle of the figure is the MS2 spectrum of the reference scan of verapamil. The spectrum at the bottom of the display is the MS2 spectrum of the scan selected by mouse-clicking in the data table.

The lengthy list of masses can be pared down using the following logic. Mass to charge values that appear at numerous retention times are most likely background ions and can be eliminated. The m/z values that appear too early or too late in the chromatogram relative to the parent drug are also candidates for elimination. Finally, those m/z values that do not exhibit at least 2-3 successive MS2 scans with similar spectra are reasonable candidates for elimination. After applying these constraints to the original table of data, only those modifications at m/z of 330.1 and 441.2 are i
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10

Related biology technology :

1. A Positive Selection Assay for Mutation Analysis in Big Blue Animals
2. Epitope-Tagging Vectors for Functional Analysis in Yeast
3. Map and Link Human Genetic Disorders with SSLP Analysis
4. CastAway Precast Gels for Rapid Automated DNA Sequence Analysis
5. Single-cell RT-PCR Analysis of Paramecium Primaurelia with the Eppendorf cMaster RTplusPCR System
6. Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn
7. Use of Transcriptor Reverse Transcriptase in Microarray Analysis
8. Increased Sensitivity in Microarray Analysis
9. Gene-Expression Analysis of TP, DPD, and TS Using the LightCycler mRNA Quantification KitsPLUS
10. Agilent 2100 Bioanalyzer Automated Analysis System
11. Analysis of Microarray Data
Post Your Comments:
(Date:9/19/2014)... , September 19, 2014 ... and Markets ( http://www.researchandmarkets.com/research/b2jxhs/micro_market ) has announced the addition ... Chromatography Columns"  report to their offering.  ... market is one of the fastest-growing segments in ... $1.2 billion in 2013, and expected to reach ...
(Date:9/19/2014)... -- The new , Healthcare and Life Sciences ... on PharmaBoardroom.com for free download , looks ... Spanish economy in 2009, and the austerity measures that followed, ... in times of trouble. "Despite the crisis, ... market, and the general conditions to invest are favorable to ...
(Date:9/18/2014)... Austin, TX (PRWEB) September 18, 2014 ... of integrated urological and interventional radiology products and ... (also known as cryotherapy and cryoablation) versus external ... Mid-Atlantic Section of the American Urological Association (MAAUA) ... , "Comparing Relative Effectiveness of Cryosurgery and ...
(Date:9/18/2014)... Sept. 18, 2014 /PRNewswire-iReach/ -- DeepResearchReports.com adds "2014 ... Acid Industry" and "2014 Deep Research Report on ... its research database. Photo - ... Report on Global and China Acetic Acid Industry" ... China and Global Acetic ...
Breaking Biology Technology:Micro Market Monitor : Global Pre-packed Chromatography Columns 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4
... ARIUS Research Inc., (TSX:,ARI), a biotechnology company ... therapeutics, today announced that Daniel S. Pereira, ... the 14th Annual BioNorth,Biotechnology and Life Sciences ... approach to drug discovery using its proprietary,FunctionFIRST(TM) ...
... (NYSE: BEC ), a leading developer, manufacturer, ... complex biomedical testing,announced today that Robert Raynor, Beckman ... 19th Annual Piper Jaffray Healthcare,Conference on Wednesday, November ... http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ) The live webcast of ...
... Smart Coatings Cites Immediate Opportunities in ... and Smart Glass -, LITTLE FALLS, N.J., Nov. ... they will no longer reimburse expenses related,to most hospital-acquired ... coatings industries to sell antimicrobial coatings,according to analysts at ...
Cached Biology Technology:ARIUS to present at BioNorth Biotechnology and Life Sciences Conference 2Beckman Coulter to Present at the 19th Annual Piper Jaffray Healthcare Conference 2Change in Medicare and Medicaid Legislation Creates Market for Antimicrobial Coatings In the U.S. 2
(Date:9/18/2014)... 18, 2014 New research into the Crimean-Congo hemorrhagic ... severe hemorrhagic disease in humans similar to that caused ... CCHFV infection. This discovery has the potential to lead ... , The research, reported in a paper ... and conducted by scientists at the Texas Biomedical Research ...
(Date:9/18/2014)... Space Station ever starts a "frequent flyers" program, fruit ... the orbiting laboratory has hosted increasing numbers of fruit ... the space station in April, and another is scheduled ... is planned to launch in December. , Fruit flies ... world-- and in space. Model organisms can reveal the ...
(Date:9/18/2014)... to acquire and creatively manipulate spoken language is unique ... past 6 million years of human evolution to make ... best candidate gene we now have," says Wolfgang Enard, ... his efforts to understand the molecular biological basis of ... The results of his latest study, undertaken in collaboration ...
Breaking Biology News(10 mins):Research milestone in CCHF virus could help identify new treatments 2Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3
... human gut is home to a teeming ecosystem of microbes ... But while the gut microbiota is interacting with our ... In a study published online in Genome Research ... a common set of viruses associated with gut microbiota in ...
... , MADISON -- The blood-brain barrier -- the filter that ... mammalian brain -- is a marvel of nature. It effectively ... and it keeps out bacteria, viruses and other agents that ... by disease, stroke and multiple sclerosis, for example, and also ...
... in which the brain grows asymmetrically, with one hemisphere becoming ... the cause of hemimegalencephaly is unknown and current treatment is ... half of the brain. In a paper published ... Genetics , a team of doctors and scientists, led by ...
Cached Biology News:Gut microbes battle a common set of viruses shared by global populations 2Blood-brain barrier building blocks forged from human stem cells 2Blood-brain barrier building blocks forged from human stem cells 3Gene mutations cause massive brain asymmetry 2Gene mutations cause massive brain asymmetry 3
The Holten mini vertical flow workbench provides a particle-free environment for sample protection against airborne contaminants....
...
Medium bottle for hybridization 250 x 35mm...
Request Info...
Biology Products: