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An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis

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Blood vessel formation is an important target in the treatment of multiple diseases including several cancer types. In the small molecule screening phase of drug discovery, animal experiments are low throughput and often technically too challenging, expensive and ambiguous to be used. Scoring the degree of blood vessel formation using an unbiased microscope approach allows this assay to be used in secondary screening applications against hundreds or thousands of putative drugs. Although cell culture experiments can currently not fully replace animal experiments, they aide in reducing the number of compounds to be tested and thus accelerate drug development and our understanding of cellular signaling events.

References:

1. Auerbach, R., Lewis, R., Shinners, B., Kubai, L., Akhtar, N. 2003. Angiogenesis Assay: A Critcial Overview. Clinical Chemistry. 49:1, 32-40.

2. Taraboletti, G., Giavazzi, R. 2004. Modelling approaches for angiogenesis. EJC . 40, 881-889.

3. Fu, X.W, Nurse, C.A., Cutz, E. 2004. Expression of functional purinergic receptors in pulmonary neuroepithelial bodies and their role in hypoxia chemotransmission. Biochem. J. 385 (3-4), 275-284.


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