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An Easy-to-Use Research Fermentor/Bioreactor

ility to order the individual components they need now and add supplemental control modules and vessels at any time, should process requirements change. To simplify ordering, prepackaged fermentation and cell culture kits are available. Autoclavable vessels, 114 L, may be selected with choice of impeller, heat blanket or water-jacket heaters, and direct or magnetic-drive motors.

The basic system consists of a vessel, a Primary Control Unit for entering and displaying process parameters, and a Power Module to control temperature, agitation and pumps.

Advanced Fermentation Kits include additional modules for pH/DO and foam/level control, as well as a pump module consisting of four pumps for feeding/harvesting operations in batch, fed-batch or perfusion modes. Advanced Cell Culture Kits further add a Gas Mix controller.

All process parameters are entered and displayed on the systems Primary Control Unit (PCU). The PCU is capable of simultaneously controlling up to four individual vessels, and displaying up to 32 parameters in English, French, Spanish, or German. BioCommand Plus, a PC-compatible data acquisition and control package, is also available for comparing historical data, trend graphing, and validation support.


CELL CULTURE RUNS
Used an Advanced Cell Culture Kit with 3.0-L water-jacketed vessel, magnetic drive and a spin-filter impeller. BioCommand software was also used to control feeding and collect data. See Table 2.


FERMENTATION RUNS
Used an Advanced Fermentation Kit with direct-drive motor and 7.5L heat-blanketed vessel. BioCommand software was also used to control feeding and collect data. See Table 3.



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