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Accurate Evaluation of the Finnigan Surveyor Autosampler Performance using a Deferred Standard

s the diagnostic capability of the DS method. The first important point is that the diagnostic is run during normal analytical operation of the instrument. A simple look at the DS peak area gives a quick indication of the performance level of the HPLC system.

The DS retention time provides more specific information about the pump performance or the possibility of leaks. DS peak shape analysis supplies detailed information about the column efficiency and may lead to early identification of performance degradation. Using the DS allows quantifying the performance of an HPLC system for each analytical run.

The same tests could be performed on one or several peaks of the sample but, because the sample is not necessarily consistent over time, the tests are less conclusive. In fact, combining analysis of peaks both from the sample and the DS may lead to a very powerful failure analysis of the chromatographic system.

A better diagnostic of the instrument leads to increased confidence in the results. Some redundancy in the analytical sequence may be eliminated without loss of confidence in the results, which leads to higher throughput, a significant contribution.

Conclusion
The DS provides valuable information on the status of a chromatographic system. During the evaluation of an autosampler, this information allows for the separation of the sources of error due to the system itself from those contributed by the autosampler.

The DS is very important in all chromatographic applications. It significantly improves the confidence in the results without calling for redundant analysis, resulting in higher throughput.

References
(1) C.L. GUILLEMIN - The Deferred Standard Review - Process Control and Quality - Vol 6, N 1 (1994) 9-25 Mr. Claude Guillemin 29A boulevard Gorbella - 06100 NICE - France E-
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