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A technique for increasing yields in bioreactors and disposable cell-culture systems


FibraCel disks are a new cell-growth matrix that dramatically increase yields in packed-bed reactors, and have also proven highly effective when used in spinners, disposable bottles and bags. New Brunswick Scientific offers two new devices that use FibraCel disks to increase productivity: the FibraStage, a simple and disposable culture system that outperforms spinners, T-flasks and roller bottles, and the CelliGen 310, an advanced benchtop bioreactor suitable for research and development or small-scale production.


What is FibraCel?
FibraCel disks are a patented, solid-support matrix for growth of both anchorage-dependent and suspension cultures. Designed for the growth of animal and insect cells (Table 1), they are predominantly used for production of secreted products such as recombinant proteins and viruses. FibraCel disks were introduced in the early 1990s, and today are used throughout the world for both research and production, including the manufacture of the worlds first licensed gene-therapy drug.

Manufactured according to cGMP guidelines, FibraCel disks are composed of a polyester nonwoven fiber bonded to polypropylene mesh, providing a three-dimensional substrate to which cells can readily attach or in which they become entrapped (Fig. 1).

In a packed-bed bioreactor, the FibraCel disk bed serves to immobilize the cells, providing a low-shear, low-foam environment, and an extremely high-surface area for cell growth. Cells remain entrapped in the disk bed throughout the run, leaving the medium cell-free for simplified medium replacement and product collection 1 . Exceptionally high yields, typically 108 cells/cm3 of bed volume depending on
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