Navigation Links
A technique for increasing yields in bioreactors and disposable cell-culture systems


FibraCel disks are a new cell-growth matrix that dramatically increase yields in packed-bed reactors, and have also proven highly effective when used in spinners, disposable bottles and bags. New Brunswick Scientific offers two new devices that use FibraCel disks to increase productivity: the FibraStage, a simple and disposable culture system that outperforms spinners, T-flasks and roller bottles, and the CelliGen 310, an advanced benchtop bioreactor suitable for research and development or small-scale production.


What is FibraCel?

FibraCel disks are a patented, solid-support matrix for growth of both anchorage-dependent and suspension cultures. Designed for the growth of animal and insect cells (Table 1), they are predominantly used for production of secreted products such as recombinant proteins and viruses. FibraCel disks were introduced in the early 1990s, and today are used throughout the world for both research and production, including the manufacture of the worlds first licensed gene-therapy drug.

Manufactured according to cGMP guidelines, FibraCel disks are composed of a polyester nonwoven fiber bonded to polypropylene mesh, providing a three-dimensional substrate to which cells can readily attach or in which they become entrapped (Fig. 1).

In a packed-bed bioreactor, the FibraCel disk bed serves to immobilize the cells, providing a low-shear, low-foam environment, and an extremely high-surface area for cell growth. Cells remain entrapped in the disk bed throughout the run, leaving the medium cell-free for simplified medium replacement and product collection 1 . Exceptionally high yields, typically 108 cells/cm3 of bed volume depending on
'"/>

Source:


Page: All 1 2 3 4

Related biology technology :

1. Food science: increasing crop yields
2. Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success
3. Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems
Post Your Comments:
(Date:9/11/2014)... research paper published this week in Science , ... and Manchester,s Nobel laureate Sir Andre Geim report a ... to applied fields, similar to sailboats driven diagonally to ... atom-thick chicken wire made from carbon but with ... superlattice state by placing it on top of boron ...
(Date:9/11/2014)... 11, 2014  Lakewood-Amedex Inc., a leading ... that the United States Patent and Trademark ... for patent application 11/673,486 entitled ,Oligonucleotide-Containing Pharmacological ... application relates to the Company,s orally-deliverable nanoRNA ... be designed to treat a wide range ...
(Date:9/11/2014)... Until recently, pets suffering from arthritic ailments had ... pain. Pill therapies are costly, can be harmful to ... , The procedure uses adult (not embryonic) animal stem ... healing power. MediVet's equipment enable veterinarians to remove a ... cells, then activate and inject the cells into the ...
(Date:9/11/2014)... Entries are now being accepted for the ... and colleagues within the healthcare industry select who wins. Now ... very best in healthcare creative campaigns. The awards are unique ... health and wellness industry. All entries are placed online, and ... in each category. , “No one knows what it ...
Breaking Biology Technology:New species of electrons can lead to better computing 2Lakewood-Amedex Receives Notice Of Allowance From The United States Patent and Trademark Office (USPTO) For A New Patent Covering Its nanoRNA Gene-Silencing Technology 2Lakewood-Amedex Receives Notice Of Allowance From The United States Patent and Trademark Office (USPTO) For A New Patent Covering Its nanoRNA Gene-Silencing Technology 3MediVet America Secures Exclusive Worldwide License with Nanofiber Veterinary 2PM360 Now Accepting Entries for 2014 Pharma Choice Awards 2
... CLEVELAND, Ohio , May 24, 2010 Simbionix ... medical professionals and the healthcare industry, is launching,two new hands-on training systems- ... revealed for the first time at,the AUA annual meeting in San ... , ...
... ... Key Data to Drive Real-time Interactive Life Science Research , ... (PRWEB) May 24, 2010 -- Genedata, a ... announced Genedata Expressionist 6 , which is a major new release of the ...
... , May 24 Dynamic, thorough, and robustly ... our newest Scientific Content Consultant, Philippe Vitat, who brings with ... Mr. Vitat has worked as a certified medical writer and ... of the World" in medical education by the International Biographical ...
Cached Biology Technology:Simbionix to Reveal Two new Products at the Upcoming American Urology Association (AUA) Annual Meeting 2Simbionix to Reveal Two new Products at the Upcoming American Urology Association (AUA) Annual Meeting 3Genedata Expressionist 6 with New Refiner MS Capabilities Debuts at 58th ASMS Conference on Mass Spectrometry 2Genedata Expressionist 6 with New Refiner MS Capabilities Debuts at 58th ASMS Conference on Mass Spectrometry 3Genedata Expressionist 6 with New Refiner MS Capabilities Debuts at 58th ASMS Conference on Mass Spectrometry 4Highly Regarded Medical Writer Joins Avant Healthcare Marketing Team 2
(Date:9/12/2014)... processing from the user,s computer on to remote servers. ... computing power that they can then access from anywhere ... a single desktop or other computer with its finite ... increased energy demands of sustaining distributed servers and having ... laptop might be shut down when it is not ...
(Date:9/12/2014)... types of dendritic cells in human skin have assorted ... psoriasis report researchers in the journal EMBO Molecular ... regulate the composition of dendritic cells in psoriatic skin ... of the disease. , "We urgently need new ... benefits to patients and reduce the incidence of known ...
(Date:9/11/2014)... Chicago residents today might have had a Wisconsin ... Illinois had been approved. It was a straight line ... south of the Rock and Mississippi River confluence. University ... the proposed northern border not been changed, the state ... footprint with the northern 51 miles of the Illinois ...
Breaking Biology News(10 mins):Cutting the cloud computing carbon cost 2Dendritic cells affect onset and progress of psoriasis 2Original northern border of Illinois was south of Chicago and Lake Michigan 2Original northern border of Illinois was south of Chicago and Lake Michigan 3
... the second oldest and the second-deepest lake in the ... Geologists led by Brown University have determined the east ... last century, and its surface waters are the warmest ... in the journal Nature Geoscience , because the ...
... Dr Steve Simpson, Senior Researcher in the University of Bristol,s ... reef fish use sound as a cue to find coral ... started finding that coral larvae which must quickly find ... they will die can do the same thing. ...
... U.S. Health and Human Services Secretary Kathleen Sebelius today ... Act funds have been awarded to construct, repair and ... country. The National Institutes of Health (NIH) National Center ... expected to create or sustain jobs nationwide and to ...
Cached Biology News:Brown geologists show unprecedented warming in Lake Tanganyika 2Brown geologists show unprecedented warming in Lake Tanganyika 3HHS Secretary Sebelius announces $1 billion in NIH Recovery Act awards for research construction 2HHS Secretary Sebelius announces $1 billion in NIH Recovery Act awards for research construction 3
... to Salmonella typhimurium The genus Salmonella is ... is composed of Gram-negative bacilli that are facultative ... the "H" or flagellar antigen (phase 1 & ... the LPS moiety) and the "Vi" or capsular ...
... 50 mg/L streptomycin sulfate, 100 mg/L kanamycin ... magnesium chloride. The use of a balanced ... generally attributed to early workers in the ... solution of inorganic salts designed to maintain ...
... The micro 1 is a dramatic breakthrough ... from 1mL with 10nL resolution, the micro 1 ... benchtop dispenser. And, the micro 1 never needs ... , Touch Screen programming on an LCD Display ...
... ( Abpromise for all tested ... Synthetic peptide: VEEESFGPQPISRLE conjugated to KLH, ... 15-29 of Human Rad51 ... Swiss Protein ID: ...
Biology Products: