Navigation Links
A new wide field-of-view confocal imaging system and its applications in drug discovery and pathology

drug target is a biological entity, usually a gene, mRNA or protein molecule, with which a pharmaceutical interacts. Advances in drug delivery require an understanding of drug design, drug stability and metabolism together with the complexities imposed by the biological system such as cell/tissue penetration, drug-target interaction, and the pharmacodynamic consequences. Fluorescence microscopy provides a comprehensive tool for investigating many of these aspects of drug delivery in single cells and whole tissue.31

Microarray techniques, especially DNA microarray and tissue microarray technologies developed recently have made a great contribution to drug discovery and pathology. Fluorescence microscopy is the key technical tool in such applications. A high throughput optical microscopy system that can perform fast, large field-of-view, and high resolution fluorecence and brightfield imaging will be valuable for both pathology and drug discovery, to match the high throughput of the microarray technologies.

1.2.1. DNA microarray

Microarray analysis is based on standard molecular biology, with a principal advantage being higher throughput and greater precision than traditional filter and blotting techniques.32 DNA microarray technology provides a global analysis of gene expression at the level of transcription. It combines standard molecular techniques with high throughout screening. Through the use of microarrays, a single experiment can assay gene expression (transcriptional profiles) across thousands of genes or even the entire genome under experimental or clinical conditions.33, 34 DNA microarrays are comprised of a library of genes immobilized in a grid on a glass microscope slide. The relative intensities of the two colored signals on individual spots are proportional to the amount of specific mRNA tra
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31

Related biology technology :

1. Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals
2. Rapid hit confirmation and early hERG liability testing using the IonWorks HT system
3. High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system
4. Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success
5. Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system
6. Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system
7. Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager
8. Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system
9. Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems
10. A technique for increasing yields in bioreactors and disposable cell-culture systems
11. An Assessment of the Eppendorf twin.tec plate performance in PCR* applications
Post Your Comments:
(Date:10/20/2014)... OR (PRWEB) October 20, 2014 Local ... participate in an investigational study of donor stem cells ... in stem cell therapy and has performed clinical stem ... this study is to determine if a single injection ... affected joints can help reduce pain and inflammation in ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report ... with analysis and forecast of revenue. , Browse ... Market report, to get an idea of the ... of the segmentation in the Asia-Pacific bromine market, ... , http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is ...
(Date:10/19/2014)... Asian Orthopedic braces and support systems report defines and segments ... revenue. The Orthopedic braces and support systems market in Asia ... at a developing CAGR of 4.4% from 2013 to 2018. ... and support systems market, to get an idea of the ... segmentation of orthopedic braces and support systems market in the ...
(Date:10/18/2014)... October 18, 2014 The Asia-Pacific ... and segments the bio-based advanced phase change material ... revenue. , Browse through the TOC of the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bio-based advanced phase change ...
Breaking Biology Technology:Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 4
... (OTC Bulletin Board: BNET) announced that notification was received,today ... System" has been granted by the Commonwealth of Australia,Patent ... The,official filing date is approved as November 8, 2001 ... date of November 8, 2021., This patent now ...
... N.J., Sept. 25 Osteotech, Inc.,(Nasdaq: OSTE ), ... for,regenerative medicine, announced today the appointment of Cato T.,Laurencin, ... joined the,Board of Directors effective September 24, 2008 and ... of the Board of Directors., Kenneth P. Fallon, ...
... Vanda,Pharmaceuticals Inc. (Nasdaq: VNDA ), a ... of clinical-stage product candidates,for central nervous system ... of Vanda Pharmaceuticals Inc. (the "Company") declared ... Right (a "Right") on each,outstanding share of ...
Cached Biology Technology:Bion Announces Approval of New Australian Patent for Low Oxygen Organic Waste Bioconversion for Livestock Waste Environmental Treatment 2Cato T. Laurencin, M.D., Ph.D. to Join Osteotech Board of Directors 2Vanda Pharmaceuticals Declares Dividend Distribution of Preferred Stock Purchase Rights 2Vanda Pharmaceuticals Declares Dividend Distribution of Preferred Stock Purchase Rights 3
(Date:10/18/2014)... Berlin, 19th October 2014 Psychological stress and stress-related ... for aging-related diseases, but the molecular mechanisms ... mechanisms may contribute to the development of ... treatments for these devastating diseases. This work ... Neuropsychopharmacology congress in Berlin., Now an international ...
(Date:10/17/2014)... of Copenhagen have shown for the first time how ... fibrosis patients, giving them the opportunity to get tremendous ... , The study also discovered the bacterial growth in ... halted or slowed down by the immune cells. The ... and helped "suffocate" the bacteria, forcing the bacteria to ...
(Date:10/16/2014)... how the bowel lining develops and, in the process, ... , The researchers produced evidence that stem cells are ... a feature of the bowel lining, and believe these ... controversial finding as scientists are still divided on the ... Chin Wee Tan and Professor Tony Burgess from the ...
Breaking Biology News(10 mins):Researchers find why depression and aging linked to increased disease risk 2Scientists opens black box on bacterial growth in cystic fibrosis lung infection 2Cryptic clues drive new theory of bowel cancer development 2
... Plant Science Center (PSC) have clarified a key epigenetic ... Arabidopsis protects cells from harmful DNA elements. Published in ... Genetics , the finding contributes to advancing our understanding ... plants and animals, opening the door to applications in ...
... Professor Cyrus Cooper, Professor of Rheumatology and Director ... has been awarded the Heberden Medal of the British ... Musculoskeletal Research Programme at the University of Southampton for ... 2003. His research programme has focused on ...
... WASHINGTONA bill in Oregon that would provide incentives to deliver ... the state,s residents and, at the same time, create hundreds ... according to a study released by Upstream Public Health in ... Health Impact Project, a collaboration of the Robert Wood Johnson ...
Cached Biology News:Discovery of DNA silencing mechanism reveals how plants protect their genome 2Oregon Farm to School bill would benefit health through job creation, study finds 2Oregon Farm to School bill would benefit health through job creation, study finds 3
... positive control for ChIP assays. Efficient fixation ... is a crucial step for the Chromatin-immunoprecipitation ... probably the most important parameter. Two major ... be taken into account: first, an excess ...
Mouse monoclonal [M2II-12] to MRP2 ( Abpromise for all tested applications). entrezGeneID: 1244 SwissProtID: Q92887...
The Programmable MP-5000P-F Power Supply can be applied for any Microfluidic application....
Rab GDP dissociation inhibitor beta...
Biology Products: