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A new wide field-of-view confocal imaging system and its applications in drug discovery and pathology

of-focus haze in the image, which can be removed by using confocal microscopy or through widefield deconvolution microscopy.28 The choice of CLSM and widefield microscopes largely depends on the type of sample, with CLSMs performing better on thick samples and widefield microscopes on thin ones if no deconvolution is applied.

1.1.4. Comparison of widefield and confocal microscopy

Confocal and widefield microscopy differ in light source, illumination mode, sensitivity, resolution, specimen thickness, light exposure, 2D/3D images, data acquisition time, and computing required.19 A detailed comparison of widefield and confocal techniques can be found in the references.6, 19 For optical sectioning of thick tissue specimens, although conventional widefield microscopy with image deconvolution analysis29 can also provide good results, CLSM is still the key technique commonly used. However, both the conventional widefield and confocal microscopes in use today are based on standard microscopy objectives. Due to the limited field-of-view of the standard objective lenses, it is necessary to take small images and use tiling techniques for large specimen imaging.

1.2. Pathology, Drug Discovery and Microarray Technologies

Light microscopy has always been a fundamental research tool in pathology. It is the means for observing both morphologic changes and molecular biological changes in cell. Especially, fluorescence confocal microscopy allows both high-resolution analysis and observation of spatially extended areas.

The drug discovery process seeks to develop a biological or chemical entity that, when administered to a patient, will improve disease symptomatology or actually treat the underlying pathophysiological basis of a particular disease state.30 A
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