Navigation Links
A new wide field-of-view confocal imaging system and its applications in drug discovery and pathology

to add contrast to such sections. The end result is to produce an amplitude object from a transparent phase object, so that the illumination light is absorbed differently across the specimen. The three lasers have wavelength lines of 633 nm (red), 535 nm (green) and 488 nm (blue). The common dyes used for tissue staining are mostly broadband dyes. Thus their absorption spectra will overlap with one or more laser lines, which makes RGB imaging using the three laser sources possible.

In confocal reflectance and epi-fluorescence imaging, the signal light is descanned by the scanning mirror so that the detection aperture tracks the focused laser spot at the specimen, and the full advantage of a confocal system, i.e., the two way rejection of out-of-focus light, is realized. In a confocal transmission configuration, however, the descanning is more technically challenging. The published solutions include the use of a second synchronized scanning system,2, 3 a complicated beam path to redirect the transmitted light back to the scan- ner,56 and the use of a nonlinear crystal as confocal pinhole for the detection of transmitted signals through second-harmonic generation without descanning.57, 58

The transmission imaging mode in the wide field-of-view system described in this paper does not implement a confocal pinhole, the transmitted light is simply detected using an RGB detector. However, the point illumina- tion of the specimen in the scanning system offers theoretically better signal-to-noise ratio than a conventional widefield microscope. The point-illumination scanning scheme does reduce the lateral background, and reduces photobleaching in the specimen. As the brightfield mode is not implemented in a confocal configuration, it is only suitable for applications in thin and stained tissue imaging.

3. APPLICATIONS IN DRUG DISCO
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31

Related biology technology :

1. Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals
2. Rapid hit confirmation and early hERG liability testing using the IonWorks HT system
3. High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system
4. Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success
5. Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system
6. Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system
7. Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager
8. Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system
9. Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems
10. A technique for increasing yields in bioreactors and disposable cell-culture systems
11. An Assessment of the Eppendorf twin.tec plate performance in PCR* applications
Post Your Comments:
(Date:12/19/2014)... Research and Markets ( http://www.researchandmarkets.com/research/fhh9rj/technology ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research Service ... detailed assessment on technological advancements and market for ... 1. The Smart Fabrics market is expected ...
(Date:12/19/2014)... Fayetteville, Arkansas (PRWEB) December 18, 2014 ... plans to locate its pilot production facility and ... further develop and produce innovative new materials that ... was chosen not only because of its historic, ... regional leaders’ efforts to attract leading edge, technology-based ...
(Date:12/19/2014)... Ed Bilsky, Ph.D., vice president for Research ... in the Neurosciences (CEN), and professor of pharmacology at ... a member of the prestigious Dana Alliance for Brain ... to receive this honor. , The Dana Alliance ... Dana Foundation. Its mission is to advance public ...
(Date:12/19/2014)... December 18, 2014 iLab Solutions, the ... appointment of Siri Bryant as the new Director of ... of Core Implementations. These two new leadership positions were ... service by ensuring that iLab continues to meet the ... last four years, iLab has been deployed at over ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2
... NEW ORLEANS , May 3 ... and the American Gastroenterological Association (AGA)Institute today announced ... About It ," at Digestive Disease Week ® 2010. ... on the front lines of the diagnosis and treatment of ...
... ... sustainability and volume, such as Jatropha and others to achieve higher sustainable ... D centre started studying and identifying some of the most cost-effective and ... as 14 non-food oil crops. With years of continuing research, experiments ...
... ... today it has won a coveted Brandon Hall bronze award for technology excellence in ... , ... 2010 -- Cobent, leaders in learning and compliance training management solutions announced today it ...
Cached Biology Technology:ACAAI and AGA Partner to Raise Awareness of Hereditary Angioedema Through 'HAE: Learn About It, Talk About It' 2ACAAI and AGA Partner to Raise Awareness of Hereditary Angioedema Through 'HAE: Learn About It, Talk About It' 3ACAAI and AGA Partner to Raise Awareness of Hereditary Angioedema Through 'HAE: Learn About It, Talk About It' 4ACAAI and AGA Partner to Raise Awareness of Hereditary Angioedema Through 'HAE: Learn About It, Talk About It' 5CJP Assesses Pongamia, Moringa, Castor, Simarouba, Algae etc. as New Sustainable Biodiesel Crops 2CJP Assesses Pongamia, Moringa, Castor, Simarouba, Algae etc. as New Sustainable Biodiesel Crops 3CJP Assesses Pongamia, Moringa, Castor, Simarouba, Algae etc. as New Sustainable Biodiesel Crops 4Cobent Wins Bronze Brandon Hall Learning Technology Award 2Cobent Wins Bronze Brandon Hall Learning Technology Award 3
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014 /PRNewswire-USNewswire/ ... a Good Clinical Practices (GCP) audit to confirm ... Administration (FDA) regulations. This accomplishment enables HITLAB to ... trials utilizing the highest principles for patient safety ... to improve global healthcare access, quality, and delivery ...
(Date:12/17/2014)... Research and Markets ( http://www.researchandmarkets.com/research/9zq33j/global_chemical ... "Global Chemical Sensor Market 2015-2019" report to ... One major trend upcoming in ... sensors in biomedical applications. Chemical sensors help in ... diagnosis during surgical procedures. The Global Chemical Sensor ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... addition of the "Global Facial Recognition Market ... http://photos.prnewswire.com/prnh/20130307/600769 Facial ... of individuals. Facial recognition system measures the overall ... jaw edges, mouth, and the distance between eyes. ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... latexes are the main ingredient in the extraction of ... of industries and essential for the manufacture of surgical ... Europe is imported, extracted fundamentally from the the ... world are Malaysia, Indonesia and Thailand, three Asian countries ...
... much less mate with artistic vigor, but the accord ... Heuschrecken [The Locusts] developed by Stefan Kaegi of Rimini ... Laubichler and Gitta Honegger who review the production in ... . "Scientists have no trouble seeing themselves as ...
... New advances for the detection of cancer led by ... of Biomedical Engineering and Science (SBES) are featured as ... Society of Chemistry,s magazine, " Lab on a Chip ... http://www.rsc.org/Publishing/Journals/lc/index.asp Microfluidics is the behavior of fluids ...
Cached Biology News:Europe seeks alternatives to natural latex from Asia 2Europe seeks alternatives to natural latex from Asia 3Scientists and cast of thousands swarm stage in Europe 2Scientists and cast of thousands swarm stage in Europe 3Advances in cancer detection research by Virginia Tech engineer featured in British magazine 2Advances in cancer detection research by Virginia Tech engineer featured in British magazine 3
Rab1A...
... to LYZL6 ( Abpromise for ... Antigen: Synthetic peptide: DWLCL AFVE ... corresponding to amino acids 46-100 of ... Gene ID: 57151 ...
Request Info...
Mouse monoclonal [DJR3] to DcR1 (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 8794 SwissProtID: O14798...
Biology Products: