Navigation Links
A new wide field-of-view confocal imaging system and its applications in drug discovery and pathology

to add contrast to such sections. The end result is to produce an amplitude object from a transparent phase object, so that the illumination light is absorbed differently across the specimen. The three lasers have wavelength lines of 633 nm (red), 535 nm (green) and 488 nm (blue). The common dyes used for tissue staining are mostly broadband dyes. Thus their absorption spectra will overlap with one or more laser lines, which makes RGB imaging using the three laser sources possible.

In confocal reflectance and epi-fluorescence imaging, the signal light is descanned by the scanning mirror so that the detection aperture tracks the focused laser spot at the specimen, and the full advantage of a confocal system, i.e., the two way rejection of out-of-focus light, is realized. In a confocal transmission configuration, however, the descanning is more technically challenging. The published solutions include the use of a second synchronized scanning system,2, 3 a complicated beam path to redirect the transmitted light back to the scan- ner,56 and the use of a nonlinear crystal as confocal pinhole for the detection of transmitted signals through second-harmonic generation without descanning.57, 58

The transmission imaging mode in the wide field-of-view system described in this paper does not implement a confocal pinhole, the transmitted light is simply detected using an RGB detector. However, the point illumina- tion of the specimen in the scanning system offers theoretically better signal-to-noise ratio than a conventional widefield microscope. The point-illumination scanning scheme does reduce the lateral background, and reduces photobleaching in the specimen. As the brightfield mode is not implemented in a confocal configuration, it is only suitable for applications in thin and stained tissue imaging.

3. APPLICATIONS IN DRUG DISCO
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31

Related biology technology :

1. Kodak in vivo imaging system: precise coregistration of molecular imaging with anatomical X-ray imaging in animals
2. Rapid hit confirmation and early hERG liability testing using the IonWorks HT system
3. High-content screening of GPCR activation with MetaXpress, AcuityXpress and the Transfluor assay system
4. Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success
5. Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system
6. Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system
7. Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager
8. Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system
9. Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems
10. A technique for increasing yields in bioreactors and disposable cell-culture systems
11. An Assessment of the Eppendorf twin.tec plate performance in PCR* applications
Post Your Comments:
(Date:7/30/2015)... VANCOUVER, Washington , July 30, 2015 ... "Biosimulation Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, ... (Drug Discovery & Development, Preclinical, Clinical Trial), by End ... the Biosimulation Market is expected to reach USD 2,107.99 ... at a CAGR of 15.29%. Browse ...
(Date:7/30/2015)...  With over 60,000 customers across the globe, ISN improves the efficiency and effectiveness ... more than 60,000 safe and reliable contractors in over 80 countries. ... ... Over 60,000 Worldwide Customers In ... Headquartered in Dallas, TX , ISN has additional ...
(Date:7/30/2015)... ... ... its 2015 growth plan and as a follow up to the recently announced expansion of ... pleased to announce that it has begun construction on a new Microbiological Laboratory. The new ... dedicated to basic USP 51, USP 61, and USP 62 testing specific to raw materials. ...
(Date:7/29/2015)... 30, 2015 According to a new ... Trends & Forecasts (2015-2020), , published by Mordor Intelligence, the ... by the end of 2020, with North America ... than 40% of the global market size. The Global market ... of 13.7% during the period of (2015-2020).      ...
Breaking Biology Technology:Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3
... Va. The American Institute of Aeronautics and Astronautics ... Science , that compiles for the first time the ... drives, warp drives, gravity control, and faster-than-light travel breakthroughs ... other star systems. , While the subject matter ...
... DCGN ) announced that on February 2, 2009, it ... "Panel") stating that the Panel,will transfer the listing of ... Nasdaq Capital Market, effective at the open of the ... Market, which is,one of the three market tier designations ...
... Uroplasty, Inc. (Amex: UPI ),a medical device ... treat voiding dysfunctions, today reported financial,results for the third ... Net,sales for the third quarter of fiscal 2009 were ... quarter. , "As we discussed ...
Cached Biology Technology:New book from AIAA explores space drives, warp drives 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 3Uroplasty Reports Third Quarter Fiscal 2009 Results 2Uroplasty Reports Third Quarter Fiscal 2009 Results 3Uroplasty Reports Third Quarter Fiscal 2009 Results 4Uroplasty Reports Third Quarter Fiscal 2009 Results 5Uroplasty Reports Third Quarter Fiscal 2009 Results 6Uroplasty Reports Third Quarter Fiscal 2009 Results 7Uroplasty Reports Third Quarter Fiscal 2009 Results 8Uroplasty Reports Third Quarter Fiscal 2009 Results 9Uroplasty Reports Third Quarter Fiscal 2009 Results 10Uroplasty Reports Third Quarter Fiscal 2009 Results 11
(Date:7/31/2015)... SHENZHEN , Chine, 31 juillet 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) sera organisée par le ... Shenzhen en Chine. ... année. Depuis son inauguration en 2006, l,ICG est ... influentes dans le domaine des « omiques » et c,est ...
(Date:7/31/2015)... -- The 10 th International Conference on Genomics (ICG-10, ... 2015, in Shenzhen , China ... th anniversary this year. Since its inauguration in 2006, ... meetings in the ,omics, fields, and is one of the ... ICG-10 focuses on recent breakthroughs and advances in ,omics, research ...
(Date:7/23/2015)... Inc. (NASDAQ: AWRE ), a leading supplier of biometrics ... quarter ended June 30, 2015.  Revenue for ... of 33% compared to $6.8 million in the same quarter ... was $0.3 million, or $0.01 per diluted share, which compared ... same period a year ago.  Lower revenue ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3The 10th International Conference on Genomics (ICG-10) to Open in October 2Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
... testing for hereditary breast cancer are associated with cancer-related ... of whether women had been able to leave the ... October issue of Genetics in Medicine , official ... The journal is published by Lippincott Williams & ...
... rely on friends to help get what they need and, ... the University of Wisconsin-Madison, many microbes, plants and animals benefit ... was funded by the National Science Foundation (NSF) and published ... Science , describes the complex relationship between a beetle, two ...
... the United States and other nations commit to the path ... sustainable practices in an industry that will, as MBL scientist ... way." In a paper published in the Oct. 3 ... call for science-based policy in the emerging global biofuels industry, ...
Cached Biology News:Study looks at psychological impact of gene test for breast cancer 2Study looks at psychological impact of gene test for breast cancer 3Beetles get by with a little help from their friends 2Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability 2Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability 3
Evi-1 Antibody Shipping Temperature: Cold Storage Temperature: -20C...
Profilin-1/2 (FL-140)...
Immunogen: Synthetic peptide: N(171) H G F L S A D Q QL I K(183) Storage: -20 C, Avoid Freeze/Thaw Cycles...
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
Biology Products: