Navigation Links
Genome Wide Profiling of Paired Cancerous and Normal Breast Tissues and Rapid Interpretation of Gene Expression Data

cted for cluster analysis using the GeneSpring Software application for all 12 samples (Figure 4). Twodimensional clustering analysis was obtained from gene expression values based on the similarity of their foldchange patterns. The nomal and metastasis tumor tissue samples formed their own distinct clusters and were easily distinguishable with this analysis. For the primary tumor samples, the expression pattern of patient 1 is close to that of the normal tissue sample cluster, whereas the expression pattern of patient 2 is closer to that of the metastasis tumor sample cluster.

Gene Classification

The gene annotation provided in the Oracle Database is an important component of the Expression Array System. This versatile tool empowers researchers to quickly find useful information on genes of interest and make direct data comparisons between platforms and laboratories using annotation such as gene name and symbol, RefSeq, NMs, LocusLink, dBEST, etc.

In addition the Oracle Database includes, when known, gene annotation that pertains to gene molecular function and biological processes. Two classification systems are employed; the Panther Classification system devised by Celera Genomics and the publicly available Gene Ontology (GO) annotations. In this study we used the Panther classifications to rapidly interpret gene expression data from the various normal and diseased tissue states.

For instance, among the 2,508 genes studied in this experiment, 200 genes differentially expressed between normal and cancer tissues with p-values < 0.01 were classified by the Panther system to be involved in various signal transduction pathways. This was considered notable since the signal transduction pathway has been implicated in breast cancer. Figure 4B shows the cluster analysis of the differential expression levels of these genes. From this analysis we can
'"/>

Source:


Page: All 1 2 3 4 5 6 7

Related biology technology :

1. New BL21-CodonPlus Cells Correct Codon Bias in GC-Rich Genomes
2. Protocol for GenomePlex Whole Genome Amplification from Buccal Swab
3. Protocol for GenomePlex Whole Genome Amplification from Blood Card
4. Protocol for GenomePlex Whole Genome Amplification from Plant
5. Protocol for GenomePlex Whole Genome Amplification from Soil
6. Protocol for GenomePlex Whole Genome Amplification from Whole Blood
7. Protocol for GenomePlex Whole Genome Amplification from Formalin-Fixed Parrafin-Embedded (FFPE) tissue
8. Bacterial Whole Genome Array Analysis
9. Cenix-Designed siRNAs for 95% of Human and Mouse Genomes
10. Oragene and Whole Genome Amplification with GenomiPhi
11. Amplification of genome-representative DNA from limited sources with GenomePlex WGA technology for use in genetic alterations studies
Post Your Comments:
(Date:7/24/2014)... July 24, 2014 Three companies from ... in Livestrong’s Big C Competition. Out of 700 competition ... headed to the semi-final round. In this round twenty ... accelerator program, complete with mentoring from thought-leaders and medical ... part of the angelMD commitment to the Livestrong vision ...
(Date:7/24/2014)... balances – 4 steps – One Recommendation: the web-based ... narrows down the mass of product choices to a ... , First, select the working environment, then enter the ... define the accuracy – it’s really that simple. Specifying ... to models that fit best with the customer’s industry ...
(Date:7/24/2014)...   Cypher Genomics, Inc., the genome ... Adam Simpson as president and chief operating ... annotation and interpretation of individual human genomes for ... technology has the potential to play a transformative ... optimizing therapeutic approaches and reducing adverse drug reactions," ...
(Date:7/23/2014)... Emirates (UAE) (PRWEB) July 23, 2014 ... recently announced that its biobanking project, Provia ... Ph.D. to its growing Advisory Board. Scott Wolf ... pleased to have Dr. Vaught onboard with Provia’s ever-expanding ... and expertise that Provia’s management team brings to this ...
Breaking Biology Technology:3 angelMD Startups Make Livestrong Big C Semi-finals 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 4
... 18 eResearchTechnology,Inc. (eRT), (Nasdaq: ERES ), ... ePRO and other services to the pharmaceutical,biotechnology, medical ... J. McKelvey, the Company,s President and Chief Executive,Officer, ... are,scheduled to present at the UBS Global Life ...
... TORONTO, Sept. 18 /PRNewswire-FirstCall/ - ARIUS Research Inc., ... next wave of,antibody therapeutics, today announced that ARIUS ... plan of arrangement,involving the Company and Roche., ... September 16, 2008, ARIUS,shareholders and warrant holders approved ...
... Quick Traction in the Region, FREDERICK, Md., Sept. ... sales agent it announced,last week, Abdulkader Al-Mehyar Moh,d Basheer ... the Middle Eastern region., "We are pleased that ... is,finding wide marketing acceptance for our products. We look ...
Cached Biology Technology:eResearchTechnology, Inc. to Present at the UBS Global Life Sciences Conference on September 23rd, 2008 2ARIUS sale approved by shareholders 2BioElectronics Corp. Announces $400,000 in New Orders From the Middle East 2
(Date:7/23/2014)... Defense recently awarded the STEMPREP Project at Southern ... its goal of increasing the number of minorities ... middle school students for the two-summer classroom phase ... students with summer opportunities at research labs. , ... School of Education and Human Development, boasts an ...
(Date:7/23/2014)... Honey bees, especially the young, are highly sensitive ... together to maintain temperatures within a narrow range. Recently ... at Tufts University,s School of Arts and Sciences, is ... heat within a hive in process similar to how ... vessels and skin. , "This study shows how ...
(Date:7/23/2014)... fur seals, alongside decades of in-depth monitoring, has ... change on a population of top-predators. Published in ... that the seals have significantly altered in accordance ... with climate conditions. Despite a shift in the ... passing down through generations, leaving the population in ...
Breaking Biology News(10 mins):Department of Defense awards $2.6 million grant to SMU STEM program for minority students 2How honey bees stay cool 2Genetic study shows major impact of climate change on Antarctic fur seals 2Genetic study shows major impact of climate change on Antarctic fur seals 3
... the body's motor nerve cells grow along proper paths ... inhibiting spinal-cord neurons from regenerating after injury, researchers at ... the researchers found that a component of myelin ?a ... in adult vertebrates ?chemically blocks the ability of nerve ...
... for the first time that bacteria, in addition to ... sparkling wine known as Cava. They report their findings ... Society for Microbiology. , "Bacteria found in Cava samples ... in terms of aroma, flavor, bubble size and bubble ...
... hanging basket style device is at the heart of a plan ... sex drive of a major pest of fruit ... that very same pest. The device allows growers to selectively ... killing other beneficial insects. , The researchers at Warwick HRI, the ...
Cached Biology News:Researchers find molecule that inhibits regrowth of spinal nerve cells 2Researchers find molecule that inhibits regrowth of spinal nerve cells 3After the yeast is gone bacteria continue to develop flavor of sparkling wine 2Hanging baskets of sex and death help fruit growers 2
RECK (F-20)...
... This adapter allows ... (AB-0800 and AB-1000) PCR ... in the ABI PRISM® ... contact ABgene® for information ...
... Eliminates nonspecific products due to inactivity ... allows extension through DNA regions which contain ... an 'A' overhang ,TEMPase II is ... Polymerase that remains inactive at room ...
... solution. Cleaves a-(1-3)- and ... and glycoproteins. It is particularly efficient for ... pH must be neutral or above, for ... Unit Definition: One unit will hydrolyze ...
Biology Products: