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World TB Day Donation Campaign Increases Access to Improved TB Tests in Resource-Limited Settings
Date:3/21/2011

technology.  In 2007, the WHO endorsed liquid culture technology as the standard of care for TB diagnosis and patient management.

Laboratory diagnosis of TB largely relies on the direct microscopic examination of sputum specimens. However, the technique has low and variable sensitivity and cannot identify drug-resistant strains. Mycobacterial culture is more sensitive, but growth of TB bacilli on traditional solid media typically requires two to four weeks, and as many as eight weeks, of incubation. This consequently delays appropriate treatment in the absence of a confirmed diagnosis.

Liquid culture systems reduce delays in obtaining results by one to two weeks over solid media.  For drug susceptibility testing, the interval may be reduced to as little as 10 days, compared with 28 to 42 days with conventional solid media. Liquid systems are more sensitive for detection of mycobacteria and may increase the case yield by 10 percent over solid media.  With increased sensitivity and reduced delays, liquid systems may contribute significantly to improved patient management.

Expanding culture capacity is urgently needed to address challenges due to the epidemics of HIV-associated TB and drug-resistant TB, especially in resource-limited settings.

About BD's TB Collaborating Partners

The Earth Institute's Millennium Villages project offers a unique, holistic, innovative model for empowering rural communities to lift themselves out of extreme poverty. With the help of new advances in science and technology, local staff members work with villages to create and implement low cost, sustainable, community-led action plans that are tailored to the villages' specific needs and designed to achieve the Millennium Development Goals.

FIND is dedicated solely to developing affordable, easy-to-use and cutting edge diagnostic tests that save lives in the poorest areas of the world. From the initial id
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