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Transposagen Expands Field of Use for piggyBac Technology
Date:10/15/2009

re-program cells to become induced pluripotent stem (iPS) cells. In the long-term piggyBac may even be used for human gene therapy."

As part of the licensing deal, Transposagen will be responsible for distribution of piggyBac to researchers working in academia and other not-for-profit institutes and will also control commercial sublicenses. "We will now be able to provide piggyBac to pharmaceutical companies as a novel tool for drug and biomarker discovery," said Ostertag.

"This new license with Transposagen will greatly expand the commercial use of piggyBac," said Dr. Malcolm Fraser, professor in the Department of Biology at the University of Notre Dame.

Transposagen's new Vice President of Research, Joseph Ruiz, Ph.D., is a world expert in stem cell and iPS cell technology and will provide expertise in developing some of Transposagen's new laboratory models which incorporate iPS technology, including rat models with fully humanized organs. In addition to establishing an Animal Stem Cell Core at the Indiana University School of Medicine in 2002, Dr. Ruiz was most recently the Director of Research and Development at Vesta Therapeutics (Research Triangle Park), where he was responsible for developing protocols for manufacturing stem cell-derived hepatic (liver) cells for drug discovery and therapeutic applications.

"Transposagen and Notre Dame are staying on the cutting edge of new mobile DNA and non-embryonic stem cell technologies," said Dr. Ruiz. "Non-embryonic stem cell technologies share most of the therapeutic promise of embryonic stem cells, without having the ethical dilemmas. The piggyBac field of use expansion will ideally position Transposagen as a leader in this very promising new area."

About Transposagen Biopharmaceuticals:

Transposagen Biopharmaceuticals, Inc., a Lexington, KY based company, is the worldwide leader in the creation of unique genetical
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SOURCE Transposagen Biopharmaceuticals, Inc.
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