Navigation Links
Schering-Plough Announces Phase II and III Data for Corifollitropin Alfa
Date:7/1/2009

ul>

About REALIZE

In this single-center, open-label, uncontrolled, pilot study, 50 women undergoing ovarian stimulation prior to IVF or ICSI were down-regulated with daily injections of 0.1 mg of GnRH agonist (starting on cycle day 21). Ovarian stimulation was started with a single dose of corifollitropin alfa (100 mcg or 150 mcg) followed by daily rFSH (follitropin beta) from stimulation day eight until the day of triggering oocyte maturation. Final oocyte maturation was induced by administration of hCG as soon as three follicles 17 mm or greater were present. Vaginal progesterone was administered for luteal phase support. Patients with proven poor response were excluded from participation. The main endpoint of this trial was ovarian response. The observed number of follicles, serum estradiol levels and number of oocytes indicated a relatively high ovarian response. Corifollitropin alfa was well tolerated and there were no serious adverse events or cases of OHSS.(6)

Key Findings

  • Both the 100 mcg and 150 mcg dose groups recruited a large number of follicles 11 mm or greater with mean (SD) values of 17.5 (+/-5.5) and 18.3 (+/-6.4), respectively on the day of hCG and median serum estradiol levels of 10,019 and 10,221 pmol/L, respectively.(6)
  • The mean (SD) number of oocytes retrieved per started cycle was 15.4 (+/-6.7) in the 100 mcg dose group and 17.8 (+/-5.1) in the 150 mcg dose group.(6)

About corifollitropin alfa

Corifollitropin alfa is an investigational product being developed as a potential treatment in Controlled Ovarian Stimulation (COS) for the development of multiple follicles in women participating in an Assisted Reproductive Technology (ART) program. Corifollitropin alfa is designed as a sustained follicle stimulant (SFS) with the same pharmacodynamic profile as rFSH, but with a markedly prolonged duration
'/>"/>

SOURCE Schering-Plough
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7 8 9

Related biology technology :

1. PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation
2. Schering-Plough Announces Pricing of Senior Notes Offering
3. Schering-Plough to Webcast Presentation at Merrill Lynch Global Pharmaceutical, Biotech & Medtech Conference
4. Schering-Plough Receives Approval from European Commission for Planned Acquisition of Organon BioSciences N.V.
5. Schering-Plough Completes Acquisition of Organon BioSciences
6. Schering-Plough Wins Three of Scrips Top Pharma Industry Awards
7. Schering-Plough Schedules Conference Call and Webcast for 2007 Fourth Quarter, Full-Year Financial Result
8. Schering-Plough to Webcast Presentation at Morgan Stanley Pharmaceutical CEOs Unplugged Conference
9. Schering-Plough Announces New Drug Application for Sugammadex Assigned Priority Review Status by U.S. FDA
10. Schering-Plough Announces Sugammadex New Drug Application Filed in Japan
11. FDA Grants Priority Review for Schering-Ploughs Peginterferon Alfa-2b for the Adjuvant Treatment of Patients With Stage III Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2009)... food, and dietary supplement products with strong scientific roots and ... ... North Brunswick, NJ and Blauvelt, NY (PRWEB) December 17, ... of foods and pharmaceuticals, and RFI Ingredients, a manufacturer of ... a Memorandum of Understanding (MOU) covering a range of areas ...
(Date:12/16/2009)... have found that certain cardiac pacemakers may inadequately ... resonance imaging (MRI) scan due to the magnetic ... pacemaker. This inadequate stimulation is potentially dangerous ... to research published in BioMed Central,s open access ... is an imaging technique that uses a magnetic ...
(Date:12/16/2009)... 16 WaferGen Biosystems, Inc. (OTC Bulletin ... analysis systems, today announced that it will be ... service for gene-expression profiling using its SmartChip(TM) Real-Time ... the most comprehensive human microRNA panel of 885 ... SmartChip service offers customers the use of its ...
(Date:12/16/2009)... INDIANAPOLIS, Dec. 16 /PRNewswire/ -- ... Indiana,s life sciences industry and an active venture ... Company, Indiana State Teachers Retirement Fund, Indiana University, ... M. Fairbanks Foundation, and Credit Suisse today announced ... million venture capital fund of funds. ,, Organized ...
Breaking Biology Technology:WellGen, Inc. and RFI Ingredients to Collaborate on Therapeutic Nutrition Opportunities 2WellGen, Inc. and RFI Ingredients to Collaborate on Therapeutic Nutrition Opportunities 3FDA researchers identify new MRI safety risk for patients with pacemakers 2WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 2WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 3WaferGen to Launch Human MicroRNA Panel for Gene-Expression Profiling of 885 MicroRNA for Its Service Using the SmartChip(TM) Real-Time PCR System 4Indiana Industry, University and Community Leaders Capitalize on Next Generation of State's Life Sciences Growth 2Indiana Industry, University and Community Leaders Capitalize on Next Generation of State's Life Sciences Growth 3Indiana Industry, University and Community Leaders Capitalize on Next Generation of State's Life Sciences Growth 4Indiana Industry, University and Community Leaders Capitalize on Next Generation of State's Life Sciences Growth 5
... April 21 At the Annual General Meeting of ... all the motions proposed by the Board of Directors. ... for the business year 2008, an increase of 25% ... of the share capital to CHF 9,459,984.90 through the ...
... Inc. (Nasdaq: ITMN ) announced today that it ... 30, 2009 at 4:00 p.m. Eastern time. A live ... 4:30 p.m. Eastern time that same day. , ... 973-200-3372 (international), conference ID# 95970767. To access the webcast, ...
... E&K Scientific, the premier provider of laboratory supplies and instrumentation ... release of its specialty Accuflow product line, supporting the local ... ... San Jose, CA (Vocus) April 21, 2009 -- E&K Scientific, ...
Other Biology Technology:Syngenta holds Annual General Meeting 2InterMune to Release First Quarter Financial Results on April 30 2E&K Scientific Announces New Accuflow Product Line 2E&K Scientific Announces New Accuflow Product Line 3
(Date:12/16/2009)... for more than 4 billion years before humans showed ... eons more. That suggests they may have something to ... bacteria expert Prof. Eshel Ben-Jacob of the Raymond and ... the study of bacteria, presents compelling evidence to suggest ... not automatically opt for the swine flu H1N1 shot. ...
(Date:12/16/2009)... Calif., Dec. 2 DigitalPersona, Inc., ... solutions, today announced an agreement with IBM ... DigitalPersona biometric fingerprint technology on IBM SurePOS ... offering allows point-of-sale applications to more easily ... transactions can be linked to the individuals ...
(Date:12/16/2009)... N.J., Dec. 9 BIO-key International, ... in finger-based biometric identification solutions, today announced ... most respected security publications, named BIO-key International ... the Access Control sub-category Biometrics. ,, (Logo: ... Peter Stephenson, technology editor, SC Magazine, "Biometric ...
Breaking Biology News(10 mins):Bacteria wouldn't opt for a swine flu shot 2Bacteria wouldn't opt for a swine flu shot 3DigitalPersona Fingerprint Sensor Technology Ships on IBM SurePOS 500 Retail Systems 2BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 2BIO-key(R) Selected as 2009 Industry Innovator in Biometrics by SC Magazine 3HealthYes 21 Provides Free Preventive Screening in Support of Round Rock Express 53802 1HealthYes 21 Provides Free Preventive Screening in Support of Round Rock Express 53802 2HealthYes 21 Provides Free Preventive Screening in Support of Round Rock Express 53802 3Symposium to discuss geoengineering to fight climate change at the ESA Annual Meeting 9496 1Symposium to discuss geoengineering to fight climate change at the ESA Annual Meeting 9496 2Health reform proposals could help 13 million uninsured young adults gain coverage 53798 1Health reform proposals could help 13 million uninsured young adults gain coverage 53798 2Health reform proposals could help 13 million uninsured young adults gain coverage 53798 3
... -- Rice University bioengineers have reported an advance ... as natural factories to produce medicines, food flavorings ... available online and slated to appear in the ... journal Biotechnology Progress. , "The species of periwinkle ...
... N.J. Monmouth University,s Urban Coast Institute will host ... 31, 2007, from 10 a.m. to 12 p.m., in ... of an Ocean Literate Society: Building Communities for Action," ... means of communication will be used to increase the ...
... New Haven, Conn.Newly created neurons in adults rely on ... and survival before they can communicate with existing neighboring ... of adult neural stem cells to replace brain cells ... researchers report in The Journal of Neuroscience. , In ...
Other Biology News:Could 'hairy roots' become biofactories? 2Abel to receive posthumous Ocean and Coastal Leadership award 2
... In 1959, McCoy and his ... requirements for in vitro cultivation ... studies were performed using,Basal Medium ... create a new medium known ...
Eagle's Ham's amino acids; EHAA...
... The active ingredient in Molecular Probes. ... appears to act as a free ... emission. Our original SlowFade formulation (S-2828) ... rate of fluorescein to almost zero ...
... more than doubles the benefits of high ... analysis cycles of the standard binary system ... tandem mode. Difficult separations are dramatically improved ... heartcut configurations, on-line sample preparation is fully ...
Biology Products: