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Researchers reveal why some pain drugs become less effective over time
Date:4/3/2012

ing to define how drugs produce their desired and non desired effects, so as to avoid the second, Pineyro said. "If we can understand the chemical mechanisms by which drugs produce therapeutic and undesired side effects, we will be able to design better drugs."

Once activated by a drug, receptors move from the surface of the cell to its interior, and once they have completed this 'journey', they can either be destroyed or return to the surface and used again through a process known as "receptor recycling." By comparing two types of opioids DPDPE and SNC-80 the researchers found that the ligands that encouraged recycling produced less analgesic tolerance than those that didn't. "We propose that the development of opioid ligands that favour recycling could be away of producing longer-acting opioid analgesics," Pineyro said.


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Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

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