Navigation Links
Researchers reveal why some pain drugs become less effective over time
Date:4/3/2012

MONTREAL, April 3, 2012 Researchers at the University of Montreal's Sainte-Justine Hospital have identified how neural cells like those in our bodies are able to build up resistance to opioid pain drugs within hours. Humans have known about the usefulness of opioids, which are often harvested from poppy plants, for centuries, but we have very little insight into how they lose their effectiveness in the hours, days and weeks following the first dose. "Our study revealed cellular and molecular mechanisms within our bodies that enables us to develop resistance to this medication, or what scientists call drug tolerance," lead author Dr. Graciela Pineyro explained. "A better understanding of these mechanisms will enable us to design drugs that avoid tolerance and produce longer therapeutic responses."

The research team looked at how drug molecules would interact with molecules called "receptors" that exist in every cell in our body. Receptors, as the name would suggest, receive "signals" from the chemicals that they come into contact with, and the signals then cause the various cells to react in different ways. They sit on the cell wall, and wait for corresponding chemicals known as receptor ligands to interact with them. "Until now, scientists have believed that ligands acted as 'on- off' switches for these receptors, all of them producing the same kind of effect with variations in the magnitude of the response they elicit," Pineyro explained. "We now know that drugs that activate the same receptor do not always produce the same kind of effects in the body, as receptors do not always recognize drugs in the same way. Receptors will configure different drugs into specific signals that will have different effects on the body."

Pineyro is attempting to tease the "painkilling" function of opioids from the part that triggers mechanisms that enable tolerance to build up. "My laboratory and my work are mostly structured around rational drug design, and trying to define how drugs produce their desired and non desired effects, so as to avoid the second, Pineyro said. "If we can understand the chemical mechanisms by which drugs produce therapeutic and undesired side effects, we will be able to design better drugs."

Once activated by a drug, receptors move from the surface of the cell to its interior, and once they have completed this 'journey', they can either be destroyed or return to the surface and used again through a process known as "receptor recycling." By comparing two types of opioids DPDPE and SNC-80 the researchers found that the ligands that encouraged recycling produced less analgesic tolerance than those that didn't. "We propose that the development of opioid ligands that favour recycling could be away of producing longer-acting opioid analgesics," Pineyro said.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related biology technology :

1. Researchers Identify New Regulator in Allergic Diseases
2. CNIO researchers take part in the most comprehensive personalized medicine study performed to date
3. Researchers develop graphene supercapacitor holding promise for portable electronics
4. Researchers capture first-ever images of atoms moving in a molecule
5. Penn researchers build first physical metatronic circuit
6. Pitt researchers coax gold into nanowires
7. York researchers create tornados inside electron microscopes
8. Self-assembling nanorods: Berkeley Lab researchers obtain 1-, 2- and 3-D nanorod arrays and networks
9. Navy researchers investigate small-scale autonomous planetary explorers
10. Notre Dame researchers develop paint-on solar cells
11. Quantum computing has applications in magnetic imaging, say Pitt researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. ... STACS DNA as a Field Application Specialist. , “I am thrilled that Dr. ... STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings a ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the ... Convention Center and will showcase its product’s latest features from June 26 to ... a scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... June 22, 2016  Amgen (NASDAQ: AMGN ... QB3@953 life sciences incubator to accelerate the ... shared laboratory space at QB3@953 was created to help ... obstacle for many early stage organizations - access to ... sponsorship, Amgen launched two "Amgen Golden Ticket" awards, providing ...
Breaking Biology Technology:
(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
(Date:6/3/2016)... , June 3, 2016 ... von Nepal hat ... Lieferung hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung ... in der Produktion und Implementierung von Identitätsmanagementlösungen. ... Ausschreibung im Januar teilgenommen, aber Decatur wurde ...
(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
Breaking Biology News(10 mins):