New Data Show Rubicon's Unique Amplification Technology Enables Genetic And Epigenetic Analyses of Single Cells Using Next-Generation ... (-- it has similar performance to the exi...)

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New Data Show Rubicon's Unique Amplification Technology Enables Genetic And Epigenetic Analyses of Single Cells Using Next-Generation Sequencing

Date:11/1/2010

-- it has similar performance to the existing kits but add enhanced profiling capabilities afforded by next-generation sequencing, such as the ability to conduct aneuploidy and CNV analyses and to profile genomic regions using single sequencing lanes.

At the 2010 ASHG meeting, Rubicon is presenting NGS data from small tissue samples prepared using its new whole methylome amplification technology for preparation of DNA libraries for epigenetic research.(2) Next-generation DNA sequencing has revolutionized epigenetic research by enabling the profiling of differentially-methylated DNA regions associated with cancer and other diseases. However, current protocols for preparing the libraries needed for these analyses require days of complex and laborious preparation. Rubicon's MethylPlex-NGS WMA is a streamlined, automatable process for preparation of libraries for genome-wide methylation profiling. It is substantially simpler, more sensitive and faster than existing methods, requiring only 20-50 nanograms of input DNA and 4.5 hours of total preparation time. MethylPlex WMA also deletes non-relevant sequences and ensures enrichment of the highly methylated DNA fragments.

In studies of human prostate cancer and benign cell lines, researchers using the MethylPlex WMA technology showed that MethylPlex WMA provided accurate identification of regions of the genome that are important for describing the differences in gene expression of cancer and normal cells.

PicoPlex-NGS WMA will be the first kit to provide DNA methylation profiling at the single-cell level. Rubicon envisions this technology will make possible more detailed studies of how embryonic cells differentiate into complex tissues and how cancer cells switch genes on and off. The reliability and sensitivity of PicoPlex-NGS WMA will also enable studies aimed at understanding how stem cells can be re-programmed to have different functions within th
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SOURCE Rubicon Genomics
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