Date:7/31/2009

nch of Qutenza; the tolerability profile and/or benefits of NeurogesX' product candidates and potential development partners for NeurogesX' early-stage products. Such statements are based on management's current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to the FDA may request additional clinical trials or other information prior to granting approval for Qutenza; any regulatory approvals which are received may be limited to certain indications; NeurogesX' product candidates may have unexpected adverse side effects or inadequate therapeutic efficacy or tolerability; and other difficulties or delays in, clinical development of, and obtaining regulatory approval for NeurogesX' product candidates. For further information regarding these and other risks related to NeurogesX' business, investors should consult NeurogesX' filings with the Securities and Exchange Commission.

    NeurogesX, Inc.                     The Ruth Group
    Stephen Ghiglieri                   Sara Pellegrino (investors)
    Chief Financial Officer             (646) 536-7002
    (650) 358-3310                      spellegrino@theruthgroup.com

                                        Jason Rando (media)
                                        (646) 536-7025
                                        jrando@theruthgroup.com

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SOURCE NeurogesX, Inc. Copyright©2009 PR Newswire. All rights reserved

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