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Laboratory Test May Predict Effectiveness of ERBITUX(R) for Individual Colorectal Cancer Patients
Date:6/1/2009

lifetime," said Dr. Holly Gallion, Vice President Clinical Affairs, Precision Therapeutics, "Studies such as this move us a step closer to increasing the accuracy of the chemotherapy and biologic decision-making process for oncologists and their patients."

About the Study

The chemoresponse assay (ChemoFx(R)) was developed using four different immortalized carcinoma cell lines (designated; NCI-H292, NCI-H522, NCI-H1666, Calu3). The chemoresponse assay was also performed on 54 cultures of primary human colorectal cancer. Cell lines and specimens were treated with a serial dose of 10 concentration of cetuximab for 72 hours, stained with a nuclear dye, and remaining post-treatment live cells were counted. Two of the examined cell lines showed response to cetuximab treatment; EC50 values for NCI-H292 and NCI-H1666 were 825nM and 13nM, respectively. NCI-H522 and Calu3 were deemed non-responsive to cetuximab. Dose-response curves of the 54 primary colorectal cultures revealed that eight (8) percent of the cultures tested were responsive to cetuximab, 22 percent had an intermediate response, and 70 percent were deemed non-responsive. These results are consistent with a reported clinical response for cetuximab in colorectal carcinoma patients.

About Precision Therapeutics

Precision Therapeutics is a diagnostics services company dedicated to providing physicians and patients with actionable clinical information to personalize cancer treatments. Precision Therapeutics is a leader in the development and delivery of treatment support tools that assist physicians and benefit cancer patients. For more information visit www.precisiontherapeutics.com, call 800-547-6165 or email '/>"/>

SOURCE Precision Therapeutics, Inc.
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