Navigation Links
iGEM team helps prevent rogue use of synthetic biology
Date:8/7/2010

A team of students from ENSIMAG, an engineering school in Grenoble, France, and Virginia Tech is using bioinformatics to implement federal guidance on synthetic genomics. The students' work will help gene synthesis companies and their customers better detect the possible use of manufactured DNA as harmful agents for bioterrorism.

Synthetic biology offers huge potential for practical applications in medicine, energy production, agriculture, and other areas. For a few thousand dollars, it is now possible to design custom DNA sequences the size of a viral genome, order these sequences from a DNA manufacturer, and receive the DNA in the mail within a few weeks. Experts are concerned, however, about the potential misuse of these emerging technologies and that is where the student's project could play a key role in preventing synthetic biology malpractice.

Jean Peccoud, associate professor at the Virginia Bioinformatics Institute (VBI) at Virginia Tech and leader of Virginia Tech's iGEM initiatives, said, "The students have taken great strides in implementing different possible interpretations of the federal recommendations. Their work characterizes the relationship between the computational cost of the screen and its sensitivity. This independent scientific analysis will identify practical solutions compatible with the operational constraints of commercial operators and refine policies aimed at protecting the nation without undermining its competitiveness."

Algorithms under development assess how similar a specific DNA sequence is to entries in the Centers for Disease Control and Prevention's Select Agent and Toxin List. Keyword lists help to track down matches and allow for continual fine-tuning of the effectiveness of each search. The students are compiling a database of test cases that allows them to estimate the performance of different screening strategies.

Edward You, supervisory special agent in the Federal Bureau of Investigation's (FBI) Weapons of Mass Destruction Directorate, had the opportunity to visit VBI on June 4 and gave a seminar entitled "Biosecurity: The roles and responsibilities of academia and law enforcement". During his visit, he met with some of the students working on the iGEM project. "The students should be commended for tackling a real-life problem directly related to national security needs," said Agent You. By working on this significant project, they are actively participating in the development of responsible practice for this transformative science, which is exactly what the government of this country wants to encourage." He added: "It is very promising to see undergraduate students at iGEM engage their peers in thinking about biosecurity. The groundbreaking work of this international team impacts the safety of people around the globe."

Skip Garner, executive director of VBI, commented: "This project would not have been possible without the support of the MITRE Corporation and Science Applications International Corporation. The sponsorship of these two industrial organizations, widely recognized for their expertise in defense and security, will certainly help transform these scientific results into meaningful outcomes for society."

The final results of the Virginia Tech-ENSIMAG biosecurity team's analyses will be presented in November at the International Genetically Engineered Machines (iGEM) synthetic biology competition organized by the Massachusetts Institute of Technology.


'/>"/>

Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

Related biology technology :

1. Bigge Helps Build New USTAR Complex at the University of Utah
2. Elekta / Mitsubishi Electric Collaboration Helps Japans Gunma University Heavy Ion Medical Center Launch Advanced Carbon Ion Therapy for Treating Cancer
3. Online Video of InVitria's Zap-CHO Helps Scientists Maximize CHO Cell Culture Performance
4. Thermofab Helps Brookfield Engineering Move To A Compact Custom Plastic Enclosure
5. Cryo-Cell Internationals Stem Cell Research and Development Helps the Fight Against Breast Cancer
6. FLAVORx Helps Families Fight Pandemic H1N1 Influenza Virus By Making Antiviral Medicine Taste Better
7. New Call Center Helps Ovarian Cancer Patients Cope With Challenges of Diagnosis
8. MRI simulation of blood flow helps plan childs delicate heart surgery
9. AIAG Helps Automotive Manufacturers Diversify into Medical Device Marketplace
10. Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance
11. High-Tech Smart Face Mask Helps Hong Kong Families Combat Swine Flu
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... 2017   Parent Project Muscular Dystrophy (PPMD) , ... Duchenne muscular dystrophy (Duchenne) , today announced a $600,000 ... of Technology (NJIT) and Talem Technologies (Talem) as part ... to assist people living with Duchenne. PPMD is ... an embedded computer, software, a force sensor and a ...
(Date:1/18/2017)... ... January 18, 2017 , ... Total Orthopedics and Sports Medicine ... Solofuse-P™. The operation took place on Wednesday, January 11, 2017 at Long Island ... anterior cervical discectomy and fusion on a 42 year old female who was ...
(Date:1/18/2017)... ... January 18, 2017 , ... Announced in December ... Institutes (MII). U.S. Secretary of Commerce Penny Pritzker has announced the award of ... of Defense has announced the award of a new Advanced Regenerative Manufacturing Institute ...
(Date:1/18/2017)... ... 18, 2017 , ... Researchers from a new study are stating that if levels ... prostate cancer treatment, this indicates there is still remaining prostate cancer cells that are more ... PSA test has always been an indicator of whether a man’s prostate cancer is ...
Breaking Biology Technology:
(Date:12/15/2016)... and BADEN-BADEN, Germany , December 15, ... global financial services provider, today announced an agreement with NuData ... biometrics, to join forces. The partnership will enable clients to ... in compliance with local data protection regulation. ... In order to provide ...
(Date:12/15/2016)... ... has announced the addition of the "Global Military Biometrics Market 2016-2020" ... global military biometrics market to grow at a CAGR of 7.5% during ... on an in-depth market analysis with inputs from industry experts. The report ... The report also includes a discussion of the key vendors operating in ...
(Date:12/15/2016)... HILLS, Mich. , Dec. 15, 2016  There ... unlocking car doors or starting the engine. Continental will ... in Las Vegas . Through the ... (Passive Start and Entry) and biometric elements, the international ... field of vehicle personalization and authentication. "The ...
Breaking Biology News(10 mins):