Navigation Links
deCODE genetics Uncovers Impact of Mutations in The Human Genome on Cognitive Ability

REYKJAVIK, Iceland, Dec. 18, 2013 /PRNewswire/ -- deCODE genetics, a global leader in analyzing and understanding the human genome, reported today in the journal Nature that mutations associated with an increased risk of schizophrenia and autism also affect cognition in individuals without the disease or intellectual disability. The research suggests that cognitive abnormalities are fundamental in schizophrenia, yet outward signs of the disease only manifest in a subset of carriers of the mutations.

"This study provides one of the first footholds into biochemical understanding of humans' unique cognitive abilities," said study lead author Kari Stefansson, M.D., Dr. Med., CEO of deCODE genetics. "At the same time, these results raise important questions as to why certain mutations impact some individuals more dramatically than others."  

Certain copy number variants (CNVs), one type of mutation, have been previously identified as strong risk factors for schizophrenia and autism, neuropsychiatric diseases which affect cognition. Researchers sought to understand what, if any, impact these CNVs may have on cognitive ability in disease-free carriers.

They administered neuropsychiatric tests to 1,268 individuals across four groups (schizophrenia patients, control carriers of neuropsychiatric CNVs, control carriers of other CNVs and population controls), and found that carriers of CNVs that predispose to neuropsychiatric disease have cognitive abilities between people without the CNVs and people with schizophrenia.

"Our results suggest that neuropsychiatric CNVs can be used as an instrument for further study of the cognitive abnormalities that characterize schizophrenia, because whether or not an individual develops this disease is likely related to the expression of these genes," said Stefansson. "The findings also provide insight into which cognitive abilities put individuals at risk of developing schizophrenia and demonstrate that control carriers provide an opportunity to study cognitive abnormalities without the confounding effects of psychosis or medication."  

About deCODE

Headquartered in Reykjavik, Iceland, deCODE genetics is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases ranging from cardiovascular disease to cancer. deCODE genetics is a subsidiary of Amgen. deCODE's corporate information can be found at

Media Contact:
Tom Langford

SOURCE deCODE genetics
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. deCODE Genetics, in Collaboration with Academic Colleagues, Discovers Three Variants in the Sequence of the Human Genome that Affect the Risk of Thyroid Cancer
2. Scientists decode brain waves to eavesdrop on what we hear
3. Human Genome Decoder and Artificial Life Creator, J. Craig Venter to Speak at "The Atlantic Meets the Pacific"
4. NextCODE Health Launches Operations with Exclusive License to Leverage deCODE genetics Genomics Platform for Sequence-Based Clinical Diagnostics, and $15 Million in Venture Financing
5. Interleukin Genetics Reports Third Quarter 2011 Financial Results
6. Metamark Genetics Signs Collaboration Agreement on Novel Therapeutic Targets with Janssen Biotech
7. Ambry Genetics Launches Illumina MiSeq Next-Gen Sequencing Services
8. Cytogenetics - Technologies, Markets and Companies
9. GeneThera, Inc. Acquires Applied Genetics, S.A.
10. Genetics Policy Institute (GPI) Files Additional Legal Arguments in Sherley v. Sebelius Stem Cell Case
11. Good Start Genetics Announces $14M Series B Financing, Expands Senior Management Team
Post Your Comments:
(Date:11/27/2015)... , November 27, 2015 ... Growing popularity of companion diagnostics is ... cancer biomarkers market with pharmaceutical companies and ... companion diagnostic tests. . ... Complete report on global cancer biomarkers ...
(Date:11/25/2015)... 2015 --> ... - 2020 report analyzes that automating biobanking workflow ... in long-term samples, minimizing manual errors, improving the ... manual errors such as mislabeling or inaccurate sample ... plays a vital role in blood fractionation, DNA ...
(Date:11/25/2015)... , November 25, 2015 ... cat and human plaque and pave the way for more ... problems in cats     --> ... most commonly diagnosed health problems in cats, yet relatively little ... now. Two collaborative studies have been conducted by researchers from ...
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ - Aeterna Zentaris ... that its business and prospects remain fundamentally strong ... Zoptrex™ (zoptarelin doxorubicin) recently received DSMB recommendation to ... completion following review of the final interim efficacy ... 2 Primary Endpoint in men with heavily pretreated ...
Breaking Biology Technology:
(Date:10/29/2015)... 2015 NXTD ) ("NXT-ID" ... on the growing mobile commerce market and creator ... a leading marketplace to discover and buy innovative ... wallet on StackSocial for this holiday season.   ... "Company"), a biometric authentication company focused on the ...
(Date:10/27/2015)... 2015 Synaptics Inc. (NASDAQ: SYNA ), the ... has adopted the Synaptics ® ClearPad ® ... its newest flagship smartphones, the Nexus 5X by LG ... --> --> Synaptics works closely ... collaboration in the joint development of next generation technologies. ...
(Date:10/23/2015)... 23, 2015 Research and Markets ( ... Voice Recognition Biometrics Market 2015-2019" report to their ... The global voice recognition biometrics market to grow ... --> --> The report, ... based on an in-depth market analysis with inputs from ...
Breaking Biology News(10 mins):