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deCODE genetics Announces First Quarter 2008 Financial Results
Date:5/1/2008

dependent and irrespective of whether patients were

receiving concomitant therapy with aspirin. The company is now

concluding a second clinical pharmacology study of the effects of DG041

when taken with aspirin and Plavix(TM). deCODE is also working on a

once-daily formulation for DG041 and is exploring partnership

opportunities for the latter phases of development of DG041.

Target Discovery

-- Nicotine addiction and lung cancer. In April, deCODE scientists

reported a clear link between a single SNP and susceptibility to

nicotine dependence. Moreover, in part because of this impact on

smoking behavior, each copy of the risk variant of this SNP confers an

approximately 30% increase in risk of lung cancer and a 20% increase in

risk of peripheral arterial disease (PAD), a common and debilitating

constriction of the arteries to the legs. Roughly half of people of

European descent carry at least one copy of the variant, which the

deCODE team estimates to account for some 18% of lung cancers and 10%

of cases of PAD. These are also perhaps the highest-impact risk factors

yet found for either condition. deCODE plans to apply these findings in

the development of a DNA-based test which can be used to aid in

personalizing and increasing the effectiveness of smoking cessation

efforts, and of predicting risk of lung cancer and PAD.

About deCODE

deCODE is a biopharmaceutical company applying its discoveries in human genetics to the development of diagnostics and drugs for common diseases. deCODE is a global leader in gene discovery - our population approach and resources have enabled us to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer, genes that are providing us with drug targets rooted in the basic biology of disease. Through its CLIA
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4. U.S. Preventive Medicine and deCODE Genetics Sign Letter of Intent to Expand Personalized Medicine Platform
5. A Smoking Gene: deCODE Shows How a Single Variant in the Sequence of the Genome Confers Nicotine Dependence and Risk of Lung Cancer and Other Disease
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