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deCODE genetics Announces First Quarter 2008 Financial Results
Date:5/1/2008

e in genotyping and data management. In the past three months,

subscribers have received updates on novel genetic factors involved in

prostate cancer, breast cancer, nicotine addiction and lung cancer,

osteoporosis, intracranial and abdominal aortic aneurysm, and human

fertility and evolution.

-- Heart attack - DG051. In January, the company announced positive

results from its Phase IIa clinical testing of DG051, deCODE's

developmental compound for the prevention of heart attack. DG051,

discovered by deCODE chemists, is designed to counter risk of heart

attack by reining in the activity of the leukotriene pathway, reducing

the production of the pro-inflammatory molecule leukotriene B4 (LTB4).

The results of the Phase IIa study confirmed that DG051 delivers

significant dose-dependent reductions in LTB4 in patients with a

history of heart attack or coronary artery disease and who were taking

a variety of concomitant medications. The pharmacokinetic and safety

profiles of the compound were favorable and similar to those seen in

previous studies in healthy volunteers. The company is actively seeking

a partner with whom to take the next steps in development of its

leukotriene program.

-- Arterial thrombosis: DG041. DG041 is deCODE's novel, first-in-class

antagonist of the EP3 receptor for prostaglandins E2, being developed

as a next-generation oral anti-platelet therapy for preventing arterial

thrombosis without increasing bleeding time. In clinical studies to

date, DG041 has been shown to dramatically inhibit platelet aggregation

as well as platelet activation mediated specifically through

vasodilator-stimulated phosphoprotein (VASP), a biomarker useful for

measuring platelet activity. These effects have been shown to be

concentration-
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SOURCE deCODE genetics
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4. U.S. Preventive Medicine and deCODE Genetics Sign Letter of Intent to Expand Personalized Medicine Platform
5. A Smoking Gene: deCODE Shows How a Single Variant in the Sequence of the Genome Confers Nicotine Dependence and Risk of Lung Cancer and Other Disease
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