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deCODE genetics Announces First Quarter 2008 Financial Results
Date:5/1/2008

se of these variants, 10% of

men are at twice the risk and 1% of men are at three times the risk of

the disease in the general population.

-- Diagnostics: Breast cancer. In April, deCODE published its discovery of

the fourth set of common SNPs associated with risk of estrogen

receptor-positive (ER+) breast cancer. The latest SNPs are on

chromosome 5p12, and although these variants confer modest risk, they

are so common that they are estimated to account for approximately 11%

of breast cancers overall. With this latest discovery, the genetic

factors underpinning a very significant proportion of inherited risk of

ER+ breast cancer have now been elucidated. Common variants previously

discovered by deCODE on chromosomes 2q35 and 16q12 are together

involved in an estimated 25% of ER+ breast cancers. The analysis in the

April paper also reveals that a fourth known set of variants, located

on chromosome 10q26 and accounting for approximately 16% of breast

cancers, appear to confer risk exclusively of ER+ tumors. deCODE is

applying these variants as the basis for a DNA-based reference

laboratory risk-assessment test the company plans to launch in the

coming months. Such a test will allow for the identification of women

who may benefit from regular screening with standard as well as new,

high-resolution technologies.

-- deCODEme(TM). In the first quarter deCODE continued to fold its range

of new gene discoveries into the deCODEme(TM) personal genome analysis

service. The company is leveraging its breakthrough discoveries in the

marketing of deCODEme(TM), underscoring the advantages to subscribers

of choosing a genome analysis service that is not just a website, but

rather a portal to world-leading science and more than a decade of

experienc
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SOURCE deCODE genetics
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Related biology technology :

1. deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer
2. deCODE Lauds Federal Legislation to Ban Discrimination on the Basis of Genetic Information
3. deCODE genetics Announces Webcast of Conference Call to Discuss First Quarter 2008 Financial Results
4. U.S. Preventive Medicine and deCODE Genetics Sign Letter of Intent to Expand Personalized Medicine Platform
5. A Smoking Gene: deCODE Shows How a Single Variant in the Sequence of the Genome Confers Nicotine Dependence and Risk of Lung Cancer and Other Disease
6. deCODE genetics to Webcast Presentation at 15th Annual Future Leaders in the Biotech Industry Conference
7. deCODE genetics to Webcast Presentation at Lehman Brothers Eleventh Annual Global Healthcare Conference
8. deCODE Genetics Announces Full-year 2007 Financial Results
9. deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2007 Financial Results
10. deCODE genetics to Webcast Presentation at BIO CEO and Investor Conference
11. deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women
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