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deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke
Date:11/10/2008

g stroke, and physicians can immediately take this new information into the clinic through the use of the same test. This has implications for the prevention of recurrent stroke, because most patients who have suffered a cryptogenic or large vessel event are discharged and put on Plavix or aspirin, which have little impact in preventing AF. Testing all of their stroke and TIA patients with deCODE AF(TM), doctors can identify those who should be monitored for AF. And for those who evidence AF, warfarin may be the best therapy. With our partner Medicomp we are now planning a multicenter study pairing the use of deCODE AF(TM) with ambulatory digital cardiac monitors, in order to demonstrate the impact that improving the detection of AF cna have on the prevention of stroke," said Dr. Kari Stefansson, M.D., Dr. Med., CEO of deCODE, a board-certified neurologist and neuropathologist.

About deCODE AF(TM) and this study

In 2007, deCODE discovered two SNPs on chromosome 4q25 that double the risk of atrial fibrillation, and later that year launched deCODE AF(TM) to enable doctors to detect these SNPs in their patients. In the study discussed above, deCODE conducted a genome-wide association study to identify risk variants for stroke. The deCODE team analyzed more than 300,000 single latter variations (SNPs) across the genomes of more than 35,000 stroke patients and control subjects from several discovery and replication cohorts from the United States and Europe. The 4q25 SNPs in the deCODE AF test - called rs10033464 and rs2200733 - were the only markers found to confer significantly increased risk of ischemic stroke in general and carioembolic stroke in particular. This was not unexpected, because AF is such a major risk for ischemic stroke. However rs2200733 was also strongly associated with increased risk of non-cardiogenic stroke as well.

How to order deCODE AF(TM)

Additional information and physician order forms for deCODE AFr(TM) can be found
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SOURCE deCODE genetics Inc
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